INT185501

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Context Info
Confidence 0.02
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.08
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NEU2) small molecule metabolic process (NEU2) hydrolase activity, acting on glycosyl bonds (NEU2)
cytoplasm (NEU2)
Anatomy Link Frequency
nucleus 2
cerebrospinal fluid 1
NEU2 (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 112 97.68 Very High Very High Very High
Cannabinoid 8 92.28 High High
Neuropeptide 11 90.80 High High
Inflammation 179 89.80 High High
imagery 7 77.60 Quite High
Inflammatory stimuli 70 65.44 Quite High
depression 4 63.84 Quite High
substance P 3 55.76 Quite High
bradykinin 1 55.12 Quite High
Inflammatory response 114 54.48 Quite High
Disease Link Frequency Relevance Heat
Genetic Predisposition To Disease 1 98.24 Very High Very High Very High
INFLAMMATION 313 89.80 High High
Traumatic Stress Disorders 1 69.08 Quite High
Post-traumatic Stress Disorder 1 67.80 Quite High
Schizophrenia 4 64.84 Quite High
Manic Depressive Disorder 4 64.12 Quite High
Depression 4 63.84 Quite High
Disease 15 52.24 Quite High
Autism 9 50.00 Quite Low
Disease Progression 2 48.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In essence the model as shown in Eq. (7) captures the essential steps of the cellular signaling of steroids which include: (i) the binding of the steroid drug (D) to its cytosolic receptor (GR), (ii) the subsequent formation of the drug-receptor complex (DR) (iii) the translocation of the cytosolic complex to the nucleus (DR(N)) which alters the transcriptional machinery activating or repressing numerous genes and finally (iv) the autoregulation of the gene transcript of the glucocorticoid receptor (Rm).
Localization (translocation) of cytosolic in nucleus
1) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.18 Pain Relevance 0.26
The corticosteroid intervention envelope consists of a set of elementary interactions that involve: (i) the binding of the corticosteroid drug (D) to its cytosolic receptor (GR), (ii) the subsequent formation of the drug-receptor complex (DR) (iii) the translocation of the cytosolic complex to the nucleus (DR(N)) that alters the transcriptional machinery activating or repressing numerous genes and finally (iv) the autoregulation of the gene transcript of the glucocorticoid receptor (Rm).
Localization (translocation) of cytosolic in nucleus associated with corticosteroid
2) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.48 Pain Relevance 0.38
As a result there may be an inappropriate release of the cytosolic proteolytic enzyme PEP into the circulating blood stream and the cerebrospinal fluid (CSF).
Localization (release) of cytosolic in cerebrospinal fluid
3) Confidence 0.01 Published 2005 Journal BMC Psychiatry Section Body Doc Link PMC1190193 Disease Relevance 0.43 Pain Relevance 0.23
Based on studies with a range of inhibitors, activators and experimental conditions, we propose that Echinacea extract contains compounds other than its known alkamides that induce cytosolic Ca2+ release, in combination with an ER-depletion-associated activation of the SOCE pathway in HEK293 cells.


Localization (release) of cytosolic
4) Confidence 0.01 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.17

General Comments

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