INT185504

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Context Info
Confidence 0.68
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.92
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PREP) peptidase activity (PREP) nucleus (PREP)
cytoplasm (PREP)
Anatomy Link Frequency
chondrocytes 1
cerebrospinal fluid 1
PREP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 103 98.18 Very High Very High Very High
Neuropeptide 11 92.64 High High
depression 4 63.84 Quite High
substance P 3 55.76 Quite High
bradykinin 1 55.12 Quite High
Inflammation 16 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Genetic Predisposition To Disease 1 98.24 Very High Very High Very High
Osteoarthritis 104 98.18 Very High Very High Very High
Traumatic Stress Disorders 1 69.08 Quite High
Post-traumatic Stress Disorder 1 67.80 Quite High
Schizophrenia 4 64.84 Quite High
Manic Depressive Disorder 4 64.12 Quite High
Depression 4 63.84 Quite High
Infection 14 50.48 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 94 50.08 Quite High
Autism 9 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a result there may be an inappropriate release of the cytosolic proteolytic enzyme PEP into the circulating blood stream and the cerebrospinal fluid (CSF).
Localization (release) of PEP in cerebrospinal fluid
1) Confidence 0.68 Published 2005 Journal BMC Psychiatry Section Body Doc Link PMC1190193 Disease Relevance 0.43 Pain Relevance 0.23
Models for cost of lifetime PREP were adjusted for present discounted value (PDV) (i), and adjusted by an estimate of future years of sexual activity and PREP coverage [26] (ii):

??

Localization (coverage) of PREP
2) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912853 Disease Relevance 0.10 Pain Relevance 0
Primary OA chondrocytes (>80% confluent) were serum starved for 12 hours/overnight and then were pre-treated with different doses of PE (6.25 to 100 ?
Localization (treated) of PE in chondrocytes associated with osteoarthritis
3) Confidence 0.21 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.39 Pain Relevance 0.20

General Comments

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