INT185514

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Context Info
Confidence 0.03
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.18
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtpn) nucleus (Mtpn) cytoplasm (Mtpn)
Anatomy Link Frequency
neurons 2
brain 2
Mtpn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 4 96.76 Very High Very High Very High
Hyperalgesia 14 73.20 Quite High
ischemia 6 54.88 Quite High
Pain 13 50.00 Quite Low
cerebral cortex 5 26.36 Quite Low
nociceptor 11 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
Central grey 6 5.00 Very Low Very Low Very Low
withdrawal 6 5.00 Very Low Very Low Very Low
midbrain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperalgesia 14 73.20 Quite High
Cv Unclassified Under Development 4 54.88 Quite High
Hypoxia 5 54.52 Quite High
Pain 13 50.00 Quite Low
Pressure And Volume Under Development 2 49.92 Quite Low
Reprotox - General 1 1 12.76 Low Low
Nociception 22 5.00 Very Low Very Low Very Low
Injury 7 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 6 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
If substantiated, then rapid removal of IGF-1 from the brain reported herein may be the reason for the lesser effectiveness of this growth factor.


Negative_regulation (removal) of Positive_regulation (effectiveness) of growth factor in brain
1) Confidence 0.03 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1190198 Disease Relevance 0.11 Pain Relevance 0.15
Functional subsets of neurons can be defined by growth factor induced increases of pErk1/2 intensities on a single cell level
Negative_regulation (defined) of Positive_regulation (increases) of growth factor in neurons
2) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0.07 Pain Relevance 0.07

General Comments

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