INT185649

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Context Info
Confidence 0.20
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 10.14
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ERG) signal transduction (ERG) nucleus (ERG)
DNA binding (ERG) cytoplasm (ERG) signal transducer activity (ERG)
Anatomy Link Frequency
eyes 4
horizontal cell 1
photoreceptors 1
spike 1
ERG (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 31 100.00 Very High Very High Very High
Codeine 48 94.76 High High
Glutamate receptor 6 94.64 High High
qutenza 6 87.84 High High
antagonist 12 87.12 High High
Morphine 3 85.56 High High
ketamine 17 80.64 Quite High
withdrawal 3 76.60 Quite High
Analgesic 3 76.20 Quite High
addiction 7 75.92 Quite High
Disease Link Frequency Relevance Heat
Ocular Hypertension 419 100.00 Very High Very High Very High
Cough 153 100.00 Very High Very High Very High
Targeted Disruption 93 100.00 Very High Very High Very High
Optic Nerve Injuries 142 99.96 Very High Very High Very High
Glaucoma 53 99.36 Very High Very High Very High
Prostate Cancer 20 98.00 Very High Very High Very High
Ganglion Cysts 82 90.72 High High
Blindness 7 88.32 High High
Eye Disease 4 80.48 Quite High
Disease 30 76.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of general anesthesia on cough and ERt/ERg also differ substantially.
Regulation (effects) of ERg associated with anesthesia and cough
1) Confidence 0.20 Published 2008 Journal Cough Section Body Doc Link PMC2405785 Disease Relevance 0.77 Pain Relevance 0.41
As such, there is no difference in the response of ERt and ERg to central antitussives and this finding differs markedly from the response of cough to these drugs.
Regulation (response) of ERg associated with cough
2) Confidence 0.18 Published 2008 Journal Cough Section Body Doc Link PMC2405785 Disease Relevance 1.01 Pain Relevance 0.52
The ERt/ERg are likely produced and controlled by different mechanisms than the expulsions in cough [5,7,22,35].
Regulation (controlled) of ERg associated with cough
3) Confidence 0.09 Published 2008 Journal Cough Section Body Doc Link PMC2405785 Disease Relevance 0.97 Pain Relevance 0
Due to the rearrangement, the putative oncogene ERG becomes androgen regulated [8,9].
Regulation (regulated) of ERG
4) Confidence 0.08 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2518564 Disease Relevance 0.90 Pain Relevance 0.21
Twelve weeks after ONT, changes in ERG wave amplitudes were still observed in operated eyes from group IV rats (n=9; Figure 7A).
Regulation (changes) of ERG in eyes associated with optic nerve injuries
5) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779069 Disease Relevance 0.47 Pain Relevance 0
In pigmented rats, twelve weeks after the ONT, changes in ERG wave amplitudes were still observed in operated eyes from group VIII (n=5; Figure 7B).
Regulation (changes) of ERG in eyes associated with optic nerve injuries
6) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779069 Disease Relevance 0.54 Pain Relevance 0
The 50 male controls include the 35 ones from the OCT and ERG controls.
Regulation (controls) of ERG
7) Confidence 0.04 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519029 Disease Relevance 0.23 Pain Relevance 0
Injections of DMSO at the highest concentration (20%) had no effect on ERG amplitude (n?
Neg (no) Regulation (effect) of ERG
8) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993945 Disease Relevance 0 Pain Relevance 0.08
Since ERG measurement depends on the capture of the photon by opsin molecules located in outer segments, the preservation of this structure, in addition to the cone survival, the changes in bipolar or horizontal cell function to photoreceptor input, and synaptic connectivity from the surviving cones, is likely to underlie the synergy scored by the ERG.
Regulation (depends) of ERG in horizontal cell
9) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957406 Disease Relevance 0.05 Pain Relevance 0
Neither U73122 nor YM298198 had a significant effect on the wild type ERG in our hands (Fig. 3 E & F; Fig. 4E & F) indicating that the processes giving rise to the TKO ERG are more sensitive to these agents than are those providing the majority of the wild type response.
Regulation (effect) of ERG
10) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993945 Disease Relevance 0 Pain Relevance 0.16
Indeed, major wave components of the ERG have been shown to be severely affected in humans with glaucoma [9,10] or ocular hypertension (OHT) [11] as well as in experimental glaucoma [12].
Regulation (affected) of ERG associated with glaucoma and ocular hypertension
11) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 1.40 Pain Relevance 0
To study the effect of IOP elevation on the ERG waves in albino mice, simultaneous ERG recordings were performed on the right and left eyes of each animal before surgery.
Regulation (effect) of ERG in eyes associated with ocular hypertension
12) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.59 Pain Relevance 0
He did not, however, further investigate the spatial relationships between the RFs of different spike sources and he did not record the local ERG response.
Neg (not) Regulation (response) of ERG in spike
13) Confidence 0.02 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1192803 Disease Relevance 0.27 Pain Relevance 0
To our knowledge, we report for the first time significant decreases in STR, a-wave, and b-wave ERG scotopic responses in adult albino Swiss mice with elevated IOP.
Regulation (responses) of ERG associated with ocular hypertension
14) Confidence 0.02 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.91 Pain Relevance 0
Experimental models of elevated intraocular pressure (IOP) [13-17] have shown important alterations of several ERG components, including scotopic threshold response (STR), a-wave, and b-wave, which are associated with RGCs, photoreceptors, and bipolar cells, respectively.
Regulation (alterations) of ERG in photoreceptors associated with ocular hypertension
15) Confidence 0.02 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 1.61 Pain Relevance 0
Here, we set out to assess the extent to which modulation of the mouse cone ERG according to light adaptation and circadian phase could be explained by changes in the degree of coupling between rod and cone pathways.
Regulation (modulation) of ERG
16) Confidence 0.01 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773742 Disease Relevance 0.07 Pain Relevance 0.03
To compare the effects of atropine on the TKO ERG, mice were divided into two groups: 5 mice received atropine sulphate eye drops (1%; minims, preservative free) in each eye 30 minutes prior to recording, and 5 mice received no drops.
Regulation (effects) of ERG in eye associated with targeted disruption
17) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993953 Disease Relevance 0.34 Pain Relevance 0.08

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