INT185669

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Context Info
Confidence 0.33
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.83
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (AR) transport (AR) enzyme binding (AR)
DNA binding (AR) cell-cell signaling (AR) cytoplasm (AR)
Anatomy Link Frequency
nucleus 4
kidney 4
Mouse 2
AR (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 51 100.00 Very High Very High Very High
depression 2 88.88 High High
agonist 77 87.24 High High
addiction 5 87.20 High High
adenocard 71 85.52 High High
Angina 2 80.72 Quite High
Catecholamine 8 78.64 Quite High
antagonist 24 26.24 Quite Low
Inflammation 10 25.16 Quite Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 9 99.92 Very High Very High Very High
Depression 2 88.88 High High
Coronary Artery Disease 7 85.92 High High
Hypersensitivity 19 82.80 Quite High
Cv General 3 Under Development 2 80.72 Quite High
Prostate Cancer 27 77.28 Quite High
Neuropathic Pain 1 65.80 Quite High
Hyperlipidemia 1 62.08 Quite High
Congenital Anomalies 1 59.92 Quite High
Reprotox - General 1 4 59.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, AR was cloned from stickleback kidney RNA and the molecular structures of two splicing variants, AR?
Positive_regulation (Furthermore) of Localization (cloned) of AR in kidney
1) Confidence 0.33 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1192819 Disease Relevance 0.11 Pain Relevance 0.08
Furthermore, AR was cloned from stickleback kidney RNA and the molecular structures of two splicing variants, AR?
Positive_regulation (Furthermore) of Localization (cloned) of AR in kidney
2) Confidence 0.29 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1192819 Disease Relevance 0.11 Pain Relevance 0.08
The amino acid sequence alignments were made using sequences obtained from the GenBank sequence data bank with the following accession numbers: Human, Homo sapiens AR (M34233); Mouse, Mus musculus AR (X53779); Rat, Rattus norvegicus AR (M20133); Zebra finch, Taeniopygia guttata AR (AF532914); African clawed toad, Xenopus leavis AR (U67129); Tilapia AR?
Positive_regulation (clawed) of Localization (toad) of AR in Mouse
3) Confidence 0.29 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1192819 Disease Relevance 0.16 Pain Relevance 0
Binding of DHT to AR promotes cytosolic AR activation and the translocation of activated AR to the nucleus.
Positive_regulation (activated) of Localization (translocation) of AR in nucleus
4) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.37 Pain Relevance 0.04
They also showed that T inhibited adipogenic differentiation of pre-adipocytes by activation of androgen receptor (AR)/beta-catenin interaction and translocation of androgen receptor/beta catenin complex to the nucleus, thus bypassing canonical Wnt signalling.
Positive_regulation (activation) of Localization (translocation) of AR in nucleus associated with obesity
5) Confidence 0.14 Published 2008 Journal Cardiovasc Diabetol Section Body Doc Link PMC2576082 Disease Relevance 1.02 Pain Relevance 0.13
Substitution of the indole moiety with other (hetero)aryl nuclei, such as phenyl, naphthyl, thiophene, pyrrole, benzoimidazole or benzotriazole, did not succeed in enhancing A2B AR potency.
Positive_regulation (enhancing) of Localization (potency) of AR associated with potency
6) Confidence 0.10 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.06 Pain Relevance 0.37
2A-AR is not observed following chronic activation of ?
Positive_regulation (activation) of Neg (not) Localization (observed) of AR
7) Confidence 0.06 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0.04

General Comments

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