INT185688

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Context Info
Confidence 0.15
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.09
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TBXA2R) signal transducer activity (TBXA2R)
Anatomy Link Frequency
platelet 4
TBXA2R (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 159 97.44 Very High Very High Very High
antagonist 4 64.32 Quite High
adenocard 11 50.00 Quite Low
fibrosis 1 22.12 Low Low
bradykinin 11 14.36 Low Low
agonist 14 5.00 Very Low Very Low Very Low
Angina 8 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 114 98.66 Very High Very High Very High
Pre-eclampsia 33 90.16 High High
Atherosclerosis 2 84.64 Quite High
Myocardial Infarction 15 83.04 Quite High
Death 4 76.96 Quite High
Fibromyalgia 1 62.04 Quite High
Hypertension 5 54.96 Quite High
Coronary Artery Disease 6 50.00 Quite Low
Acute Coronary Syndrome 10 46.72 Quite Low
Rupture 2 24.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To be fully activated platelets are dependent on two positive feedback loops; the formation of thromboxane A2 by cyclooxygenase in the platelets and the release of ADP from dense platelet granules.
Regulation (dependent) of in platelets Localization (release) of thromboxane A2 in platelet
1) Confidence 0.15 Published 2005 Journal Thromb J Section Body Doc Link PMC1192820 Disease Relevance 0.08 Pain Relevance 0.15
Our results further suggest that other measures of platelet adhesion and platelet activation measured by flow cytometry are indirectly dependent on secreted ADP or TXA2.
Regulation (dependent) of Localization (secreted) of TXA2 in platelet associated with adhesions
2) Confidence 0.04 Published 2009 Journal J Transl Med Section Body Doc Link PMC2699331 Disease Relevance 0.75 Pain Relevance 0.11
As this elevation is not associated to changes in the urinary excretion of thromboxane B2, the balance favors the vasodilator versus the vasoconstrictor balance of this vasoactive pair [37].
Regulation (changes) of Localization (excretion) of thromboxane B2
3) Confidence 0.01 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.26 Pain Relevance 0

General Comments

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