INT185691

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2009
Negated 3
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 12.57
Pain Relevance 6.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
platelet 7
Plasma 2
adipose tissue 2
kidney 1
intestine 1
WDTC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 56 99.82 Very High Very High Very High
aspirin 1184 99.76 Very High Very High Very High
Inflammation 57 99.72 Very High Very High Very High
cytokine 12 97.12 Very High Very High Very High
Pain 26 96.98 Very High Very High Very High
antagonist 79 96.60 Very High Very High Very High
Angina 73 88.88 High High
Cannabinoid 60 84.24 Quite High
agonist 25 83.64 Quite High
adenocard 153 78.36 Quite High
Disease Link Frequency Relevance Heat
Obesity 184 100.00 Very High Very High Very High
Cv Unclassified Under Development 46 99.82 Very High Very High Very High
Heart Rate Under Development 27 99.80 Very High Very High Very High
INFLAMMATION 72 99.72 Very High Very High Very High
Myocardial Infarction 185 99.68 Very High Very High Very High
Acute Coronary Syndrome 101 99.48 Very High Very High Very High
Coronary Artery Disease 43 99.16 Very High Very High Very High
Reperfusion Injury 2 98.96 Very High Very High Very High
Disease 139 98.04 Very High Very High Very High
Heart Disease 266 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased levels of ADP could be one reason for increased platelet activity and aspirin resistance.


Positive_regulation (Increased) of ADP in platelet associated with aspirin
1) Confidence 0.48 Published 2005 Journal Thromb J Section Body Doc Link PMC1192820 Disease Relevance 0 Pain Relevance 0.25
ADP levels are increased in STEMI and correlates with platelet activation.
Positive_regulation (increased) of ADP in platelet
2) Confidence 0.48 Published 2005 Journal Thromb J Section Body Doc Link PMC1192820 Disease Relevance 0 Pain Relevance 0.25
The control group in this study was therefore chosen to present pain and stress and it is our belief that this control group is more relevant for comparison than unstressed healthy individuals to prove ischemia induced increases in ADP levels.
Positive_regulation (increases) of ADP associated with stress, pain and ischemia
3) Confidence 0.48 Published 2005 Journal Thromb J Section Body Doc Link PMC1192820 Disease Relevance 0.69 Pain Relevance 0.47
Then our finding of increased ADP levels may reflect an increased ADP release from platelets.
Positive_regulation (increased) of ADP in platelets
4) Confidence 0.48 Published 2005 Journal Thromb J Section Body Doc Link PMC1192820 Disease Relevance 0.61 Pain Relevance 0.40
For the first time we have demonstrated in man that ADP levels are increased during myocardial infarction.
Positive_regulation (increased) of ADP associated with myocardial infarction
5) Confidence 0.48 Published 2005 Journal Thromb J Section Body Doc Link PMC1192820 Disease Relevance 0.63 Pain Relevance 0.46
It is possible that increased ADP levels during acute myocardial ischemia could contribute to the increased frequency of aspirin resistance.
Positive_regulation (increased) of ADP associated with aspirin, coronary artery disease and ischemia
6) Confidence 0.48 Published 2005 Journal Thromb J Section Body Doc Link PMC1192820 Disease Relevance 0.63 Pain Relevance 0.43
Increased levels of ADP could be one reason for increased platelet activity and aspirin resistance.



Positive_regulation (Increased) of ADP in platelet associated with aspirin
7) Confidence 0.32 Published 2005 Journal Thromb J Section Abstract Doc Link PMC1192820 Disease Relevance 0.60 Pain Relevance 0.41
We wanted to evaluate the effect of aspirin on platelet function in patients with acute coronary syndromes and we hypothesized that increased levels of ADP in patients with acute coronary syndromes could contribute to aspirin resistance.


Positive_regulation (increased) of ADP in platelet associated with aspirin and acute coronary syndrome
8) Confidence 0.32 Published 2005 Journal Thromb J Section Abstract Doc Link PMC1192820 Disease Relevance 0.67 Pain Relevance 0.39
However, aspirin resistance could also be dependent on increased activity of the ADP positive feedback system.
Positive_regulation (increased) of ADP associated with aspirin
9) Confidence 0.32 Published 2005 Journal Thromb J Section Body Doc Link PMC1192820 Disease Relevance 0.43 Pain Relevance 0.46
Furthermore, we hypothesized that increased levels of ADP in patients with acute coronary syndromes could contribute to aspirin resistance.


Positive_regulation (increased) of ADP associated with aspirin and acute coronary syndrome
10) Confidence 0.32 Published 2005 Journal Thromb J Section Body Doc Link PMC1192820 Disease Relevance 0.76 Pain Relevance 0.69
Plasma levels of ADP were markedly increased in STEMI (905 ± 721 nmol/l, p < 0.01), but not in NSTEMI (317 ± 245), compared to NCD (334 ± 271, mean ± SD).
Neg (not) Positive_regulation (increased) of ADP in Plasma associated with heart disease
11) Confidence 0.32 Published 2005 Journal Thromb J Section Abstract Doc Link PMC1192820 Disease Relevance 0.98 Pain Relevance 0.54
ADP levels are increased in STEMI and correlates with platelet activation.
Positive_regulation (increased) of ADP in platelet
12) Confidence 0.32 Published 2005 Journal Thromb J Section Abstract Doc Link PMC1192820 Disease Relevance 0.62 Pain Relevance 0.37
These patents may benefit more from inhibitors of ADP mediated platelet activation than aspirin.
Positive_regulation (activation) of ADP in platelet associated with aspirin
13) Confidence 0.32 Published 2005 Journal Thromb J Section Body Doc Link PMC1192820 Disease Relevance 0.57 Pain Relevance 0.34
Plasma levels of ADP were markedly increased in STEMI (905 ± 721 nmol/l, p < 0.01), but not in NSTEMI (317 ± 245), compared to NCD (334 ± 271, mean ± SD) (Fig 3).
Neg (not) Positive_regulation (increased) of ADP in Plasma associated with heart disease
14) Confidence 0.32 Published 2005 Journal Thromb J Section Body Doc Link PMC1192820 Disease Relevance 0.69 Pain Relevance 0.24
As the number of adipose tissue compartments is increased, it is essential to keep the total flow (i.e. average perfusion rate FT = 0.044 l/min/kg) fixed in order to maintain the fit to the early time data.
Positive_regulation (increased) of adipose in adipose tissue associated with obesity
15) Confidence 0.05 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1797001 Disease Relevance 0.10 Pain Relevance 0
Eger et. al. [46] suggested that the high flow adipose compartment might be an artifact of intertissue diffusion from high blood flow tissues (e.g. kidney, intestine, dermis) to surrounding adipose tissue.
Positive_regulation (compartment) of adipose in intestine associated with obesity
16) Confidence 0.05 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1797001 Disease Relevance 0.17 Pain Relevance 0.04
Recent studies have suggested regional increases in ADP can trigger mitochondrial movement. [62] We used the BioVision Research Products ApoSensor ADP/ATP ratio assay kit (Mountain View, CA) to measure the ADP/ATP ratio but could not detect consistently altered levels of ATP or ADP levels (data not shown) in our PD and CNT cybrid neuronal cells after LLLT.
Positive_regulation (increases) of ADP in neuronal associated with disease
17) Confidence 0.05 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2711937 Disease Relevance 0.43 Pain Relevance 0
Secondly, if the liver clearance time constant is long compared to the adipose exchange time constant, the liver clearance becomes rate limiting and the kinetics at long times are no longer dependent on the adipose (or any other tissue) blood flow.
Neg (no) Positive_regulation (dependent) of adipose in blood
18) Confidence 0.04 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1797001 Disease Relevance 0 Pain Relevance 0
Endothelial ADPase activity is lost following ischaemia-reperfusion injury, xenograft rejection and inflammation resulting in increased levels of ATP and ADP [58, 207].
Positive_regulation (levels) of ADP associated with reperfusion injury, inflammation and cv unclassified under development
19) Confidence 0.02 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.75 Pain Relevance 0.12
Endothelial ADPase activity is lost following ischaemia-reperfusion injury, xenograft rejection and inflammation resulting in increased levels of ATP and ADP [58, 207].
Positive_regulation (increased) of ADP associated with reperfusion injury, inflammation and cv unclassified under development
20) Confidence 0.02 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.75 Pain Relevance 0.12

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