INT18570

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Context Info
Confidence 0.57
First Reported 1990
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.45
Pain Relevance 2.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (HERPUD1) molecular_function (HERPUD1) response to stress (HERPUD1)
HERPUD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antinociception 2 99.36 Very High Very High Very High
Pain threshold 1 98.92 Very High Very High Very High
Potency 1 98.14 Very High Very High Very High
narcan 1 95.76 Very High Very High Very High
Morphine 4 95.28 Very High Very High Very High
Analgesic 2 94.52 High High
analgesia 5 88.48 High High
tail-flick 1 87.80 High High
Acute pain 1 85.92 High High
opiate 7 84.00 Quite High
Disease Link Frequency Relevance Heat
Stress 137 99.96 Very High Very High Very High
Pain 2 98.92 Very High Very High Very High
Malignant Neoplastic Disease 40 50.00 Quite Low
Lung Cancer 94 5.00 Very Low Very Low Very Low
Cancer 80 5.00 Very Low Very Low Very Low
Nicotine Addiction 60 5.00 Very Low Very Low Very Low
Hypoxia 24 5.00 Very Low Very Low Very Low
Carcinoma 24 5.00 Very Low Very Low Very Low
Non-small-cell Lung Cancer 18 5.00 Very Low Very Low Very Low
Apoptosis 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Tyr-MIF-1 peptides reduced stress-induced antinociception in PP test.
Gene_expression (reduced) of MIF-1 associated with stress and antinociception
1) Confidence 0.57 Published 2004 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 15632952 Disease Relevance 0.45 Pain Relevance 1.60
The order of potency in inhibiting binding of 125I-Tyr-MIF-1 was: hemorphin and bovine casomorphins greater than Tyr-MIF-1 greater than cytochrophins greater than human casomorphins.
Gene_expression (greater) of Tyr-MIF-1 associated with potency
2) Confidence 0.53 Published 1990 Journal Life Sci. Section Abstract Doc Link 1976197 Disease Relevance 0 Pain Relevance 0.56
Whether this indicates that there are additional mechanisms that complement XBP1 activation that can result in the expression of ERdj4 and HERPUD1 (as has been reported for HERPUD1 [66]), or if minimal amounts of spliced XBP1 are sufficient to induce their expression, remains to be determined.
Gene_expression (expression) of HERPUD1
3) Confidence 0.41 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0 Pain Relevance 0
Since XBP1 alone or in conjunction with ATF6 controls the expression of a number of UPR-relevant genes (e.g., EDEM, HRD1, HERPUD1, ERdj3, P58IPK, ERdj4, and RAMP4 [19]), we conjectured that the inhibition of XBP1 splicing by CS would also prevent these transcripts from being expressed or upregulated.
Gene_expression (expression) of HERPUD1
4) Confidence 0.41 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0 Pain Relevance 0

General Comments

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