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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.09
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (GATA4) nucleus (GATA4) DNA binding (GATA4)
transcription factor binding (GATA4) cell-cell signaling (GATA4)
Anatomy Link Frequency
heart 1
GATA4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 7 75.76 Quite High
Migraine 61 67.00 Quite High
Kinase C 4 54.00 Quite High
cva 3 51.20 Quite High
agonist 3 34.80 Quite Low
opioid receptor 3 33.28 Quite Low
Kappa opioid receptor 3 22.88 Low Low
Opioid 3 14.60 Low Low
complementary and alternative medicine 27 5.00 Very Low Very Low Very Low
Acupuncture 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Defects 6 95.96 Very High Very High Very High
Patent Foramen Ovale 30 93.40 High High
Injury 5 79.16 Quite High
Headache 47 67.00 Quite High
Migraine Without Aura 7 63.12 Quite High
Migraine With Aura 18 60.32 Quite High
Stroke 10 58.32 Quite High
Paradoxical Embolism 3 52.16 Quite High
Embryonal Carcinoma 2 37.52 Quite Low
Epilepsy 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functional studies have shown a role for the GATA-4 gene in cardiac embryogenesis [21] and mutations in this gene have been found to be associated with congenital heart defects such as atrial septal defect (ASD) and patent foramen ovale (PFO) [17].
Positive_regulation (role) of GATA-4 in heart associated with patent foramen ovale and heart defects
1) Confidence 0.50 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2577932 Disease Relevance 0.87 Pain Relevance 0.27
Under these experimental conditions, ES cell exposure to MF was found to increase remarkably the expression of genes encoding for tissue-restricted transcription factors (Fig. 2), determining a consistent upregulation of GATA-4 and Nkx-2.5 mRNA (32).
Positive_regulation (upregulation) of GATA-4
2) Confidence 0.06 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193541 Disease Relevance 0.22 Pain Relevance 0.12

General Comments

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