INT185729

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Context Info
Confidence 0.52
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.07
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Tnfsf11) extracellular space (Tnfsf11) extracellular region (Tnfsf11)
plasma membrane (Tnfsf11) intracellular (Tnfsf11) response to stress (Tnfsf11)
Tnfsf11 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 77 97.60 Very High Very High Very High
psoriasis 19 94.60 High High
cINOD 2 61.52 Quite High
methotrexate 2 59.60 Quite High
Inflammation 9 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
spondylitis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Seronegative Spondarthritis 67 97.60 Very High Very High Very High
Psoriasis 22 94.60 High High
Osteoporosis 51 92.96 High High
Bone Cancer 12 87.60 High High
Osteolysis 9 68.80 Quite High
INFLAMMATION 3 60.96 Quite High
Hypercalcemia 10 42.08 Quite Low
Sacroiliitis 5 30.08 Quite Low
Postmenopausal Osteoporosis 4 22.72 Low Low
Endometriosis (extended) 6 12.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, our study is the first to report that HEP extract stimulated the expression of OPG mRNA but suppressed the expression of RANKL mRNA in the UMR 106 cell line, resulting in a dose-dependent increase in the OPG/RANKL ratio.
Negative_regulation (suppressed) of Gene_expression (expression) of RANKL mRNA
1) Confidence 0.52 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193542 Disease Relevance 0.24 Pain Relevance 0
On the other hand, the expression of RANKL mRNA in these cells was significantly downregulated by treatment with 200 ?
Negative_regulation (downregulated) of Gene_expression (expression) of RANKL mRNA
2) Confidence 0.52 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193542 Disease Relevance 0.35 Pain Relevance 0
No overall difference was noted in RANKL or OPG concentrations between the groups of patients with erosive and nonerosive PsA (Figure 1g and 1h).


Negative_regulation (noted) of Gene_expression (concentrations) of RANKL associated with arthritis
3) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945067 Disease Relevance 1.47 Pain Relevance 0.69

General Comments

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