INT18573

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Context Info
Confidence 0.45
First Reported 1982
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 0.78
Pain Relevance 9.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
head 2
heart 2
Oprl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
orphanin 126 100.00 Very High Very High Very High
agonist 19 100.00 Very High Very High Very High
opiate 13 100.00 Very High Very High Very High
narcan 8 100.00 Very High Very High Very High
Dynorphin 2 100.00 Very High Very High Very High
Kappa opioid receptor 2 100.00 Very High Very High Very High
Dopamine 10 99.96 Very High Very High Very High
opioid receptor 31 99.84 Very High Very High Very High
tetrodotoxin 3 99.76 Very High Very High Very High
antagonist 7 99.18 Very High Very High Very High
Disease Link Frequency Relevance Heat
Infarction 2 100.00 Very High Very High Very High
Bordatella Infection 8 93.64 High High
Cv Unclassified Under Development 3 87.64 High High
Myocardial Infarction 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of opiate receptor agonists on striatally-mediated head turning: an in vivo model of opiate delta receptor activation?
Regulation (Effect) of Positive_regulation (activation) of opiate delta receptor in head associated with narcan, agonist and opiate
1) Confidence 0.45 Published 1982 Journal Neuropharmacology Section Title Doc Link 6292773 Disease Relevance 0 Pain Relevance 0.97
This opiate-mediated inhibition of evoked dopamine release was antagonized in a time-dependent manner by the putative kappa-antagonist, WIN 44,441-3, suggesting that striatal kappa-receptor activation modulates dopamine release.
Regulation (modulates) of Positive_regulation (activation) of kappa-receptor associated with dopamine, antagonist and opiate
2) Confidence 0.39 Published 1988 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2836044 Disease Relevance 0 Pain Relevance 0.66
A physiologic role for nociceptin (OFQ) activation of the ORL-1 receptor (OFQR) may be to modulate opioid-induced analgesia.
Regulation (role) of Positive_regulation (activation) of nociceptin associated with orphanin, opioid and analgesia
3) Confidence 0.29 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9721727 Disease Relevance 0.08 Pain Relevance 0.86
These results demonstrate that nociceptin (OFQ) activation of ORL-1 (OFQR) can modulate mu-opioid receptor signaling in a cellular system.
Regulation (modulate) of Positive_regulation (activation) of OFQR associated with orphanin and opioid receptor
4) Confidence 0.29 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9721727 Disease Relevance 0 Pain Relevance 1.02
A physiologic role for nociceptin (OFQ) activation of the ORL-1 receptor (OFQR) may be to modulate opioid-induced analgesia.
Regulation (role) of Positive_regulation (activation) of OFQR associated with orphanin, opioid and analgesia
5) Confidence 0.29 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9721727 Disease Relevance 0.08 Pain Relevance 0.87
These results demonstrate that nociceptin (OFQ) activation of ORL-1 (OFQR) can modulate mu-opioid receptor signaling in a cellular system.
Regulation (modulate) of Positive_regulation (activation) of ORL-1 associated with orphanin and opioid receptor
6) Confidence 0.29 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9721727 Disease Relevance 0 Pain Relevance 1.02
These results demonstrate that nociceptin (OFQ) activation of ORL-1 (OFQR) can modulate mu-opioid receptor signaling in a cellular system.
Regulation (modulate) of Positive_regulation (activation) of nociceptin associated with orphanin and opioid receptor
7) Confidence 0.29 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9721727 Disease Relevance 0 Pain Relevance 1.02
A physiologic role for nociceptin (OFQ) activation of the ORL-1 receptor (OFQR) may be to modulate opioid-induced analgesia.
Regulation (role) of Positive_regulation (activation) of ORL-1 receptor associated with orphanin, opioid and analgesia
8) Confidence 0.29 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9721727 Disease Relevance 0.08 Pain Relevance 0.87
Opposing effects on infarction of delta and kappa opioid receptor activation in the isolated rat heart: implications for ischemic preconditioning.
Regulation (effects) of Positive_regulation (activation) of kappa opioid receptor in heart associated with kappa opioid receptor and infarction
9) Confidence 0.18 Published 2000 Journal Basic Res. Cardiol. Section Title Doc Link 10752540 Disease Relevance 0.27 Pain Relevance 0.43
The activation of kappa-opiate receptor by dynorphin-(1-13) had no effect on K(+)- or GLU-evoked ACh release.
Neg (no) Regulation (effect) of Positive_regulation (activation) of kappa-opiate receptor associated with dynorphin and opiate
10) Confidence 0.14 Published 1990 Journal Brain Res. Section Abstract Doc Link 1976420 Disease Relevance 0 Pain Relevance 1.75
Taken together, these results suggest that the major cardioprotective effects of the EETs depend on activation of a G(i/o) protein-coupled delta- and/or kappa-opioid receptor.
Regulation (depend) of Positive_regulation (activation) of kappa-opioid receptor associated with kappa opioid receptor
11) Confidence 0.08 Published 2010 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 20400686 Disease Relevance 0.26 Pain Relevance 0.44

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