INT185738

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 14.41
Pain Relevance 3.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd14) plasma membrane (Cd14)
Anatomy Link Frequency
macrophages 2
microglia 2
astrocytes 2
oligodendrocytes 2
immune cells 1
Cd14 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 158 99.96 Very High Very High Very High
Inflammatory mediators 24 97.28 Very High Very High Very High
cytokine 509 95.28 Very High Very High Very High
tolerance 115 94.56 High High
Potency 6 91.04 High High
Inflammation 437 89.88 High High
Intracerebroventricular 12 87.56 High High
isoflurane 1 69.60 Quite High
anesthesia 3 68.48 Quite High
Spinal cord 6 57.28 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 606 99.96 Very High Very High Very High
Syndrome 8 99.74 Very High Very High Very High
Lyme Disease 78 99.66 Very High Very High Very High
Disease 460 99.60 Very High Very High Very High
Sepsis 15 99.30 Very High Very High Very High
Drug Induced Neurotoxicity 24 99.28 Very High Very High Very High
Infection 302 98.48 Very High Very High Very High
Toxicity 10 98.36 Very High Very High Very High
Gonorrhea 18 96.28 Very High Very High Very High
Targeted Disruption 62 91.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro evidence demonstrates that blocking CD14 recognition of bacterial components ablates innate host cell inflammatory responses.
CD14 Binding (recognition) of associated with inflammatory response
1) Confidence 0.45 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2781632 Disease Relevance 0.79 Pain Relevance 0.27
The distribution of spirochetes associated with CD14+/+ and CD14?
CD14 Binding (associated) of
2) Confidence 0.33 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0 Pain Relevance 0
Here we mechanistically link these previous findings by showing that CD14 recognition of B. burgdorferi triggers p38-dependent SOCS activity to impose a tolerant phenotype within M?.
CD14 Binding (recognition) of
3) Confidence 0.33 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0.06 Pain Relevance 0.44
The distribution of spirochetes associated with CD14+/+ and CD14?
CD14 Binding (associated) of
4) Confidence 0.33 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0 Pain Relevance 0
However, contrary to these paradigms, our prior study using a mouse model of Lyme disease demonstrated an association between CD14 deficiency, increased bacterial burden, and more severe and persistent disease.
CD14 Binding (association) of associated with lyme disease and disease
5) Confidence 0.33 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2781632 Disease Relevance 0.85 Pain Relevance 0.27
Given the capacity of PI3K to phosphorylate AKT we characterized the composition of the lipid raft formed during the interaction of B. burgdorferi with CD14+/+ and CD14?
CD14 Binding (interaction) of
6) Confidence 0.33 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0 Pain Relevance 0.04
The LPS-CD14 complex, together with other adaptor proteins, binds to the toll-like receptor 4 (TLR4), which is present on microglia, but not on astrocytes, oligodendrocytes or cortical neurons [20].
CD14 Binding (complex) of in oligodendrocytes
7) Confidence 0.32 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.34 Pain Relevance 0.17
Mouse recombinant sCD14
sCD14 Binding (recombinant) of in Mouse
8) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.24 Pain Relevance 0.16
interacted with CD14 (TLR2 and TLR4 accessory protein) and was phagocytosed by cultured microglia and monocytes, resulting in activation of the cells as well as increased secretion of cytokines [38,39].
CD14 Binding (interacted) of in monocytes associated with cytokine
9) Confidence 0.28 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 1.27 Pain Relevance 0.25
The LPS-CD14 complex, together with other adaptor proteins, binds to the toll-like receptor 4 (TLR4), which is present on microglia, but not on astrocytes, oligodendrocytes or cortical neurons [20].
CD14 Binding (binds) of in oligodendrocytes
10) Confidence 0.24 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.34 Pain Relevance 0.18
Characterization of the cells for their immunophenotypic markers by fluorescent-activated cell sorting (FACS) showed that they were negative for cell lineage markers CD45, CD14, CD34, CD19, CD3, Flk-1 and positive for typical MSC surface proteins Sca-1, CD105, CD29, CD90, CD73 and CD44 (Table 1).
CD14 Neg (negative) Binding (lineage) of
11) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2270908 Disease Relevance 0.29 Pain Relevance 0
Characterization of the cells for their immunophenotypic markers by fluorescent-activated cell sorting (FACS) showed that they were negative for cell lineage markers CD45, CD14, CD34, CD19, CD3, Flk-1 and positive for typical MSC surface proteins Sca-1, CD105, CD29, CD90, CD73 and CD44 (Table 1).
CD14 Binding (negative) of
12) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2270908 Disease Relevance 0.30 Pain Relevance 0
CD14 binds also to triacylated lipopeptides facilitating their recognition by TLR2/TLR1 complexes [65] and can enhance dsRNA-mediated TLR3 activation [66].
CD14 Binding (binds) of
13) Confidence 0.17 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.07 Pain Relevance 0.04
This complex assembles with soluble or membrane bound CD14 molecules and allows recognition by the toll-like receptor 4 (TLR4) on the surface of immune cells such as macrophages.
CD14 Binding (bound) of in macrophages
14) Confidence 0.17 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440791 Disease Relevance 0.51 Pain Relevance 0.03
Zhao et al. [116] have demonstrated that mSOD1 binds to CD14, which has a role in the activation and toxicity of microglia treated with extracellular mSOD1.
CD14 Binding (binds) of in microglia associated with toxicity
15) Confidence 0.16 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 1.07 Pain Relevance 0.03
A tri-molecular complex consisting of TLR4, MD-2, and CD14 has to be complete for full cellular stimulation by aggregated A?.
CD14 Binding (complex) of
16) Confidence 0.16 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0.67 Pain Relevance 0.05
The absence of an association between CD14 and susceptibility to C. trachomatis infection might be explained by the compartmentalisation of TLR4.
CD14 Binding (association) of associated with infection
17) Confidence 0.16 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1351185 Disease Relevance 0.64 Pain Relevance 0.16
This complex assembles with soluble or membrane bound CD14 molecules and allows recognition by the toll-like receptor 4 (TLR4) on the surface of immune cells such as macrophages.
CD14 Binding (bound) of in macrophages
18) Confidence 0.13 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440791 Disease Relevance 0.51 Pain Relevance 0.03
Combining the aforementioned studies with the knowledge that CD14 can signal through TLR4, it might be hypothesized that the absence of an association between the CD14 -260 SNP and the susceptibility to C. trachomatis infection might be due to the low expression or absence of TLR4 in the lower urogenital tract.
CD14 Spec (might) Binding (association) of associated with infection
19) Confidence 0.12 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1351185 Disease Relevance 0.21 Pain Relevance 0.05
CD14 forms a complex with LPS and the LPS-binding protein (LBP) (figure 1) [19].
CD14 Binding (binding) of
20) Confidence 0.12 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1351185 Disease Relevance 0.44 Pain Relevance 0.07

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