INT185753

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Context Info
Confidence 0.03
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.67
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (YOD1) intracellular (YOD1) cellular amino acid metabolic process (YOD1)
Anatomy Link Frequency
plasma 1
YOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
carbamazepine 2 96.72 Very High Very High Very High
anticonvulsant 1 95.08 Very High Very High Very High
dexamethasone 1 93.24 High High
Potency 7 63.04 Quite High
antagonist 6 25.56 Quite Low
tolerance 5 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 108 100.00 Very High Very High Very High
Infection 16 98.24 Very High Very High Very High
Sprains And Strains 10 89.24 High High
Influenza Virus Infection 2 82.32 Quite High
Herpes Simplex Virus 2 70.88 Quite High
Exanthema 5 67.60 Quite High
Virus Diseases 1 59.08 Quite High
Communicable Diseases 1 58.44 Quite High
Emergencies 6 50.00 Quite Low
Uterine Fibroids 1 49.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Managing treatment-experienced pediatric and adolescent HIV patients: role of darunavir

Darunavir is currently the most recently approved HIV-1 protease inhibitor.

Negative_regulation (inhibitor) of HIV-1 protease associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.03 Published 2009 Journal Therapeutics and Clinical Risk Management Section Title Doc Link PMC2724190 Disease Relevance 0.29 Pain Relevance 0
ATV is an azapeptide inhibitor of the HIV-1 protease.
Negative_regulation (inhibitor) of HIV-1 protease associated with acquired immune deficiency syndrome or hiv infection
2) Confidence 0.03 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697529 Disease Relevance 0.50 Pain Relevance 0.03
Furthermore, inhibitors of CYP3A4, eg, the HIV protease inhibitors, itraconazole, erythromycin, and grapefruit juice, may inhibit the metabolism of UPA and cause increased plasma levels.


Negative_regulation (inhibitors) of HIV protease in plasma associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.01 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971744 Disease Relevance 0.10 Pain Relevance 0.14
Ganoderic acid B (8a) inhibits HIV-1 protease with an IC 50 value of 0.17 mM (20).
Negative_regulation (inhibits) of HIV-1 protease associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.01 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193547 Disease Relevance 0.78 Pain Relevance 0

General Comments

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