INT185756

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Context Info
Confidence 0.05
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.22
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ITIH4, Cd4) extracellular region (ITIH4) cell adhesion (Cd4)
enzyme binding (Cd4) cytoplasm (ITIH4)
ITIH4 (Homo sapiens)
Cd4 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 20 71.76 Quite High
chemokine 9 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
potassium channel 2 5.00 Very Low Very Low Very Low
Antinociceptive 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 71 100.00 Very High Very High Very High
Immunization 1 97.74 Very High Very High Very High
Cytomegalovirus Infection 1 93.84 High High
Vesicular Stomatitis 1 63.92 Quite High
Disease 10 61.28 Quite High
Influenza Virus Infection 2 48.52 Quite Low
Cancer 29 44.32 Quite Low
Exanthema 1 44.20 Quite Low
Herpes Simplex Virus 1 43.00 Quite Low
Opportunistic Infections 1 42.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, TNX-355 targets CD4, PRO 542 is aimed at gp120, and PRO 140 and HGS004 bind CCR5.
gp120 Binding (aimed) of CD4
1) Confidence 0.05 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.26 Pain Relevance 0.04
Besides immunostimulation, other effects of the polysaccharide–protein complexes contribute to the antiviral activity, e.g. inhibition of binding of HIV-1 gp120 to immobilized CD4 receptor and of reverse transcriptase activity of viruses (31).
gp120 Binding (binding) of CD4 associated with acquired immune deficiency syndrome or hiv infection and immunization
2) Confidence 0.00 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193547 Disease Relevance 0.97 Pain Relevance 0

General Comments

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