INT185800

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Context Info
Confidence 0.26
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.03
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SPP1, MMP1) peptidase activity (MMP1) extracellular space (SPP1)
proteinaceous extracellular matrix (MMP1) cell adhesion (SPP1) cytoplasm (SPP1)
Anatomy Link Frequency
epithelial cells 2
fibroblasts 2
SPP1 (Homo sapiens)
MMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 144 94.80 High High
cytokine 10 65.00 Quite High
Inflammation 6 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Fibrosis 130 94.80 High High
Fibrosis 18 78.00 Quite High
Adhesions 6 67.72 Quite High
Disease 12 57.52 Quite High
Internal Fibrosis 2 39.92 Quite Low
Keloid Scars 2 31.84 Quite Low
Myocardial Infarction 2 22.88 Low Low
Pulmonary Disease 6 5.00 Very Low Very Low Very Low
Hyperplasia 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fibroblasts, osteopontin up-regulated tissue inhibitor of metalloprotease-1 and type I collagen, and down-regulated matrix metalloprotease-1 (MMP-1) expression, while in A549 cells it caused up-regulation of MMP-7.
osteopontin Negative_regulation (down-regulated) of Gene_expression (expression) of MMP-1 in fibroblasts
1) Confidence 0.26 Published 2005 Journal PLoS Medicine Section Abstract Doc Link PMC1198037 Disease Relevance 0.69 Pain Relevance 0.32
Thus, in fibroblasts, osteopontin increased TIMP-1 and type I collagen and inhibited MMP-1 expression, while in alveolar epithelial cells it induced MMP-7.
osteopontin Negative_regulation (inhibited) of Gene_expression (expression) of MMP-1 in epithelial cells
2) Confidence 0.26 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.34 Pain Relevance 0.17

General Comments

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