INT185825

Context Info Confidence 0.78 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 10 Total Number 10 Disease Relevance 2.85 Pain Relevance 1.11

peptidase activity (MMP7) extracellular space (MMP7) extracellular region (MMP7) proteinaceous extracellular matrix (MMP7)

Anatomy Link Frequency epithelial cells 4 chondrocytes 1 monocytes 1 endometrium 1 fallopian tube 1 MMP7 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 14 100.00 fibrosis 216 99.20 Inflammation 46 79.12 cytokine 31 69.04 pain pelvic 4 10.48 Arthritis 10 5.00 corticosteroid 6 5.00 Osteoarthritis 6 5.00 imagery 6 5.00 anesthesia 4 5.00

Disease Link Frequency Relevance Heat Pulmonary Fibrosis 195 99.20 Choroideremia 166 97.52 Muscular Dystrophy 2 88.96 Adhesions 18 85.72 INFLAMMATION 40 79.12 Pulmonary Disease 9 74.80 Fibrosis 27 72.12 Internal Fibrosis 3 61.92 Hyperplasia 10 58.68 Keloid Scars 3 53.84

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Mutation

Event

Anatomy

Negation

Speculation

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Although the level of MMP7 secretion was the highest in the secretory phase, the difference from the proliferative phase did not reach statistical significance, neither in the endometrium nor in the fallopian tube.

Localization (secretion) of MMP7 in fallopian tube

1) Confidence 0.78 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2805671 Disease Relevance 0 Pain Relevance 0

Matrix metalloproteinase 7 (MMP7) is secreted mostly from the endometrial epithelium cells where attachment occurs and is suggested to be important in the implantation process [13].

Localization (secreted) of Matrix metalloproteinase 7 in epithelium associated with metalloproteinase

2) Confidence 0.69 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2805671 Disease Relevance 0.06 Pain Relevance 0.08

Although the level of MMP7 secretion was the highest in the secretory phase the difference from the proliferative phase did not reach statistical significance, neither in the endometrium nor in the fallopian tube.

Localization (secretion) of MMP7 in endometrium

3) Confidence 0.69 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2805671 Disease Relevance 0 Pain Relevance 0

Matrix metalloproteinase 7 (MMP7) is secreted mostly from the endometrial epithelium cells where attachment occurs and is suggested to be important in the implantation process [13].

Localization (secreted) of MMP7 in epithelium associated with metalloproteinase

4) Confidence 0.69 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2805671 Disease Relevance 0.06 Pain Relevance 0.08

This is also supported by the colocalization of MMP-7 and osteopontin in IPF epithelial cells, and by the computational relationship of the expression levels of osteopontin and MMP-7.

Localization (colocalization) of MMP-7 in epithelial cells associated with fibrosis

5) Confidence 0.65 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.71 Pain Relevance 0.32

Interestingly, osteopontin was colocalized with MMP-7 in alveolar epithelial cells of IPF lungs, and application of the weakest link models to microarray data suggested that the genes of both interacted to affect the IPF phenotype.

Localization (colocalized) of MMP-7 in epithelial cells associated with fibrosis

6) Confidence 0.53 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.49 Pain Relevance 0.22

-catenin nuclear localization in proliferative bronchiolar lesions, where it colocalized with MMP-7 [34].

Localization (colocalized) of MMP-7

7) Confidence 0.53 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.60 Pain Relevance 0.26

Although eEPCs were grouped with monocytes, some subtle mRNA transcription differences were identified such as complement components (C1QC, C1QB), matrix metalloproteinases (MMP9, MMP7, ADAMDEC1) and osteopontin (SPP1) which were higher in eEPCs than in monocytes.

Localization (higher) of MMP7 in monocytes associated with metalloproteinase

8) Confidence 0.51 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2881111 Disease Relevance 0 Pain Relevance 0.05

Interestingly, expression levels of genes encoding secreted proteins from different functional groups including CFI, CC2, NRG1, MMP7, WNT5A, RSOPO2, CSF3R, DPP4, IL1 were deregulated altered in CHM cells compared to the control.

Localization (secreted) of MMP7 associated with choroideremia

9) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.76 Pain Relevance 0.06

These redox based natural agents appear to limit cartilage breakdown by blocking the expression, production and release of matrix metalloproteases by activated chondrocytes via a NF-?

Localization (release) of matrix in chondrocytes

10) Confidence 0.02 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.18 Pain Relevance 0.04

General Comments

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