INT185829

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.93
Pain Relevance 2.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP2) extracellular space (MMP2) extracellular region (MMP2)
proteinaceous extracellular matrix (MMP2) plasma membrane (MMP2) nucleus (MMP2)
Anatomy Link Frequency
fibroblasts 2
MMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 126 100.00 Very High Very High Very High
ischemia 21 100.00 Very High Very High Very High
dexamethasone 84 98.88 Very High Very High Very High
Inflammation 107 86.28 High High
cva 48 84.00 Quite High
fibrosis 72 80.16 Quite High
cINOD 39 70.24 Quite High
cytokine 20 68.80 Quite High
Inflammatory response 3 25.00 Low Low
chemokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 15 100.00 Very High Very High Very High
Death 41 99.50 Very High Very High Very High
Apoptosis 14 98.96 Very High Very High Very High
Cancer 49 95.28 Very High Very High Very High
Disease 55 89.72 High High
Bladder Cancer 29 88.76 High High
INFLAMMATION 133 86.28 High High
Cv General 4 Under Development 14 84.00 Quite High
Renal Cancer 4 82.88 Quite High
Pulmonary Fibrosis 65 80.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activated MMP1, MMP3 and latent forms of MMP2 and MMP9 are regulated and inhibited by endogenous proteins known as tissue inhibitors of metalloproteinase TIMP1 and TIMP2 [17].
Negative_regulation (inhibited) of Positive_regulation (Activated) of MMP2 associated with metalloproteinase
1) Confidence 0.40 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.89 Pain Relevance 0.23
Kim et al. report the inhibitory effect of chitooligosaccharides (COS) on activation and expression of matrix metalloproteinase-2 (MMP-2) in primary human dermal fibroblasts (HDFs) for the first time.
Negative_regulation (effect) of Positive_regulation (activation) of matrix metalloproteinase-2 in fibroblasts associated with metalloproteinase
2) Confidence 0.28 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0 Pain Relevance 0.08
accumulation it effectively reduces the subsequent pathologic responses including elevated levels of IL-6, MMP-2 activation, and depletion of HCSM ?
Negative_regulation (reduces) of Positive_regulation (activation) of MMP-2
3) Confidence 0.28 Published 2006 Journal J Neuroinflammation Section Abstract Doc Link PMC1557842 Disease Relevance 0.48 Pain Relevance 0.45
and that inhibition of MMP-2 activation protected the cells from apoptosis [41].
Negative_regulation (inhibition) of Positive_regulation (activation) of MMP-2 associated with apoptosis
4) Confidence 0.28 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1557842 Disease Relevance 1.13 Pain Relevance 0.39
Similarly, we found that dexamethasone, which reduced HCSM cell death (Figure 1), effectively suppressed increased expression and activation of MMP-2 in response to Dutch mutant A?
Negative_regulation (suppressed) of Positive_regulation (activation) of MMP-2 associated with dexamethasone and death
5) Confidence 0.24 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1557842 Disease Relevance 1.11 Pain Relevance 0.39
Intraperitoneal minocycline at 45 mg/kg concentration twice a day (first dose immediately after the onset of reperfusion) significantly reduced gelatinolytic activity of ischemia-elevated MMP-2 and MMP-9 (p < 0.0003).
Negative_regulation (reduced) of Positive_regulation (elevated) of MMP-2 associated with ischemia
6) Confidence 0.15 Published 2006 Journal BMC Neurosci Section Abstract Doc Link PMC1543649 Disease Relevance 0.90 Pain Relevance 0.31
Additionally, we observed a concomitant increase in TIMP-1, the main inhibitor of MMP-1 (as well as MMP-2 and ?
Negative_regulation (inhibitor) of Positive_regulation (well) of MMP-2
7) Confidence 0.12 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.43 Pain Relevance 0.18

General Comments

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