INT18583

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Context Info
Confidence 0.50
First Reported 1990
Last Reported 2011
Negated 5
Speculated 2
Reported most in Body
Documents 67
Total Number 71
Disease Relevance 49.72
Pain Relevance 8.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
liver 15
skeletal muscle 13
fat 8
macrophage 7
plasma 4
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 146 99.92 Very High Very High Very High
Opioid 22 99.84 Very High Very High Very High
anesthesia 59 99.80 Very High Very High Very High
cytokine 321 99.68 Very High Very High Very High
imagery 134 99.50 Very High Very High Very High
Inflammation 537 99.48 Very High Very High Very High
tolerance 340 98.82 Very High Very High Very High
electroacupuncture 164 98.50 Very High Very High Very High
Somatostatin 26 96.92 Very High Very High Very High
narcan 2 96.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Insulin Resistance 1094 100.00 Very High Very High Very High
Targeted Disruption 570 100.00 Very High Very High Very High
Hyperinsulinism 189 100.00 Very High Very High Very High
Frailty 48 100.00 Very High Very High Very High
Chronic Renal Failure 30 100.00 Very High Very High Very High
Obesity 1955 99.98 Very High Very High Very High
Fatty Liver 16 99.90 Very High Very High Very High
Diabetes Mellitus 931 99.84 Very High Very High Very High
Acidosis 6 99.70 Very High Very High Very High
INFLAMMATION 608 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In ob/ob mice, the agonist-induced rise in glucose did not cause the insulin response, because insulin levels were not elevated by a glucose challenge.
Neg (not) Positive_regulation (elevated) of Gene_expression (levels) of insulin associated with obesity and agonist
1) Confidence 0.50 Published 1990 Journal Diabetes Section Abstract Doc Link 1976559 Disease Relevance 0.31 Pain Relevance 0.21
A higher dose of U 50488h (10 mg/kg body wt i.p.) was required to produce significant increases in lean mouse plasma insulin (81 pM at 15 min) and glucose (0.7, 1.1, and 1.7 mM at 5, 15, and 30 min, respectively).
Positive_regulation (increases) of Gene_expression (produce) of insulin in plasma
2) Confidence 0.50 Published 1990 Journal Diabetes Section Abstract Doc Link 1976559 Disease Relevance 0.32 Pain Relevance 0.35
The higher food intake in the HFL fed animals per sé may induce insulin resistance.
Spec (may) Positive_regulation (induce) of Gene_expression (resistance) of insulin in HFL associated with insulin resistance
3) Confidence 0.42 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2852377 Disease Relevance 0.60 Pain Relevance 0.03
Moreover, alternative mechanisms responsible for the induction of insulin resistance could play a role in peripheral tissues.
Positive_regulation (induction) of Gene_expression (resistance) of insulin associated with insulin resistance
4) Confidence 0.42 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2852377 Disease Relevance 0.50 Pain Relevance 0
These data show that despite a similar decrease in whole body insulin sensitivity, the insulin resistance induced by the low stearate HFP diet is characterized by peripheral insulin resistance only.
Positive_regulation (induced) of Gene_expression (resistance) of insulin in body associated with insulin resistance
5) Confidence 0.42 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2852377 Disease Relevance 0.54 Pain Relevance 0
S1, G and H) indicate that the absence of leptin affects circulating insulin levels primarily by regulating insulin expression and secretion in addition to the possibility of changes of cell survival.
Positive_regulation (circulating) of Gene_expression (levels) of insulin
6) Confidence 0.41 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.68 Pain Relevance 0
-cell proliferation in the adipocyte-deficient mice, the data presented here show that hyperinsulinemia and lower blood glucose levels precede the appearance of obesity and hyperglycemia in ob/ob and adipocyte-deficient mice, respectively, and can be ascribed in both cases to an increase in Insulin and Glucokinase expression and, to a lesser extent, to an increase in ?
Positive_regulation (increase) of Gene_expression (expression) of Insulin in blood associated with hyperglycemia, obesity and hyperinsulinism
7) Confidence 0.41 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.83 Pain Relevance 0
At the molecular level, Insulin expression was elevated to the same degree in ob/ob and ob/+;Adr?
Positive_regulation (elevated) of Gene_expression (expression) of Insulin
8) Confidence 0.38 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.57 Pain Relevance 0.13
However, since the FA composition of HFPS and HFL are not identical (table 1), we cannot exclude that other FA's or non fatty acid components of the HFL diet, in addition to stearate, contributed to the induction of hepatic insulin resistance in HFL fed animals.
Positive_regulation (induction) of Gene_expression (resistance) of insulin in HFL associated with insulin resistance
9) Confidence 0.37 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2852377 Disease Relevance 0.47 Pain Relevance 0
The major finding of this study included the following: (1) the increase in visceral adipose tissue preceded development of fatty liver and insulin resistance; (2) the increase in size of white adipocytes was an early event as the fist step to obesity; (3) adiponectin mRNA expression was markedly decreased before the decrease in its plasma levels or the development of insulin resistance; and (4) insulin resistance appeared in association with fatty infiltration and TNF-?
Positive_regulation (increase) of Gene_expression (resistance) of insulin in adipocytes associated with fatty liver, obesity, metabolic syndrome and insulin resistance
10) Confidence 0.35 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 0.90 Pain Relevance 0.03
High-fat-diet-induced insulin resistance occurs together with decreased muscle PGC-1?
Positive_regulation (induced) of Gene_expression (resistance) of insulin in muscle associated with insulin resistance
11) Confidence 0.33 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.82 Pain Relevance 0.08
Lines of evidence have demonstrated that EA is capable of improving hyperglycemia in the fasting stage, with a marked increase in plasma insulin levels in diabetic rats [14, 30].
Positive_regulation (increase) of Gene_expression (levels) of insulin in plasma associated with hyperglycemia, diabetes mellitus and electroacupuncture
12) Confidence 0.33 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.56 Pain Relevance 0.58
Role of opioid mu-receptor that has been showed to involve in the insulin-dependent diabetic rats in the induction of insulin resistance remains unclear.
Positive_regulation (induction) of Gene_expression (resistance) of insulin associated with diabetes mellitus, insulin resistance and opioid
13) Confidence 0.32 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12614914 Disease Relevance 0.58 Pain Relevance 0.39
Rapid induction of insulin resistance in opioid mu-receptor knock-out mice.
Positive_regulation (induction) of Gene_expression (resistance) of insulin associated with targeted disruption, insulin resistance and opioid
14) Confidence 0.32 Published 2003 Journal Neurosci. Lett. Section Title Doc Link 12614914 Disease Relevance 0.75 Pain Relevance 0.60
Ghrelin infusion decreased basal as well as insulin stimulated glucose disposal and induced peripheral insulin resistance but did not affect hepatic glucose production [71].
Positive_regulation (induced) of Gene_expression (resistance) of insulin associated with insulin resistance
15) Confidence 0.31 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.21 Pain Relevance 0.11
In these patients glucose disposal rate (GDR) decreased during ghrelin infusion; however this difference was not translated into a significant difference in insulin concentration, probably because the exogenous insulin by far overweighs endogenous insulin.
Positive_regulation (overweighs) of Gene_expression (overweighs) of insulin
16) Confidence 0.31 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.06 Pain Relevance 0.07
Ghrelin infusion decreased basal as well as insulin stimulated glucose disposal and induced peripheral insulin resistance but did not affect hepatic glucose production [71].
Positive_regulation (induced) of Gene_expression (resistance) of insulin associated with insulin resistance
17) Confidence 0.31 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.21 Pain Relevance 0.11
The improvement in glucose homeostasis in ghrelin KO ob/ob mice was accompanied by increased serum insulin levels.
Positive_regulation (increased) of Gene_expression (levels) of insulin associated with targeted disruption and obesity
18) Confidence 0.31 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 2.10 Pain Relevance 0.03
In these patients glucose disposal rate (GDR) decreased during ghrelin infusion; however this difference was not translated into a significant difference in insulin concentration, probably because the exogenous insulin by far overweighs endogenous insulin.
Positive_regulation (overweighs) of Gene_expression (overweighs) of insulin
19) Confidence 0.31 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.06 Pain Relevance 0.07
Since not only macrophages, but also a variety of other immune cells are highly abundant in the obese adipose tissue and contribute to the development of obesity-induced insulin resistance [12], [13], [24], we assessed mRNA expression of different immune cell markers in the stromal vascular (SV) fraction of WAT from obese control- and IR?
Positive_regulation (induced) of Gene_expression (resistance) of insulin in macrophages associated with obesity and insulin resistance
20) Confidence 0.30 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.36 Pain Relevance 0

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