INT185852

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Context Info
Confidence 0.29
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.50
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BAK1, BAX) endoplasmic reticulum (BAK1, BAX) cytosol (BAK1, BAX)
aging (BAK1) intracellular (BAK1) cytoplasm (BAX)
BAK1 (Homo sapiens)
BAX (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 27 10.16 Low Low
antagonist 30 9.24 Low Low
cytokine 11 6.88 Low Low
COX-2 inhibitor 54 5.00 Very Low Very Low Very Low
agonist 31 5.00 Very Low Very Low Very Low
cINOD 20 5.00 Very Low Very Low Very Low
metalloproteinase 7 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
qutenza 3 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 329 100.00 Very High Very High Very High
Parkinson's Disease 1 83.36 Quite High
Reprotox - General 1 4 68.24 Quite High
Stress 7 53.84 Quite High
Lymphatic System Cancer 8 51.52 Quite High
Death 66 50.00 Quite Low
Breast Cancer 35 50.00 Quite Low
Carcinoma 6 44.64 Quite Low
Cancer 254 44.56 Quite Low
INFLAMMATION 29 10.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Short peptides representing alpha-helical BH3 domains of Bid or Bim are capable of inducing oligomerization of Bak and Bax to release cytochrome c.
Bak Binding (oligomerization) of Bax
1) Confidence 0.29 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.73 Pain Relevance 0
Bax can form also a complex with the anti-apoptotic protein Bcl-xL [53] and Mcl-1 [14].
anti-apoptotic protein Binding (complex) of Bax associated with apoptosis
2) Confidence 0.05 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.10 Pain Relevance 0
proapoptotic molecules such as Bax and Bak through heterodimerization through
Bak Binding (heterodimerization) of Bax
3) Confidence 0.03 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.67 Pain Relevance 0

General Comments

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