INT185856

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.73
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BAD, BCL2L1) mitochondrion (BAD, BCL2L1) cytoplasm (BAD, BCL2L1)
lipid binding (BAD) growth (BCL2L1) cytoskeleton (BCL2L1)
BAD (Homo sapiens)
BCL2L1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 52 44.52 Quite Low
Inflammation 26 5.00 Very Low Very Low Very Low
cINOD 17 5.00 Very Low Very Low Very Low
cytokine 11 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
metalloproteinase 7 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 226 100.00 Very High Very High Very High
Death 39 99.24 Very High Very High Very High
Papillomavirus Infection 1 95.52 Very High Very High Very High
Stomach Cancer 5 95.48 Very High Very High Very High
Pancreatic Cancer 49 93.68 High High
Cancer 205 92.56 High High
Malignant Neoplastic Disease 5 92.52 High High
Lung Cancer 8 88.16 High High
Lymphatic System Cancer 6 77.96 Quite High
Prostate Cancer 8 77.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The interaction between Bcl-X–BAD (PDB 2BZW) was missed by our analysis because the ligand bound structure (2YXJ:N3C) was published too recently to be classified in the current SCOP domain database.
BAD Binding (interaction) of Bcl-X
1) Confidence 0.39 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2816688 Disease Relevance 0.10 Pain Relevance 0
For instance, desphosphorylation of Bad allows it to interact with Bcl-xL and initiate cell death [43].
Bad Binding (interact) of Bcl-xL associated with death
2) Confidence 0.23 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.90 Pain Relevance 0
The nonphosphorylated form of Bad plays a pro-apoptotic role, by binding Bcl-xL or Bcl-2 and, thus, preventing their interactions with Bak and Bax.
Bad Binding (binding) of Bcl-xL associated with apoptosis
3) Confidence 0.03 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.92 Pain Relevance 0
Phosphorylation prevents Bad from binding either Bcl-2 or Bcl-XL and thus suppresses apoptosis.
Bad Binding (binding) of Bcl-XL associated with apoptosis
4) Confidence 0.01 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.81 Pain Relevance 0

General Comments

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