INT185877

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Context Info
Confidence 0.33
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.37
Pain Relevance 4.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (DCN) aging (DCN) extracellular region (DCN)
proteinaceous extracellular matrix (DCN)
Anatomy Link Frequency
brain 3
blood 2
extracellular matrix 2
spleen 1
DCN (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 87 99.00 Very High Very High Very High
Inflammation 5 96.48 Very High Very High Very High
Analgesic 6 93.04 High High
Pain 87 90.56 High High
withdrawal 90 89.84 High High
Calcitonin gene-related peptide 9 88.44 High High
c fibre 3 85.64 High High
algogenic 3 82.76 Quite High
bradykinin 3 80.72 Quite High
lidocaine 54 77.76 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 5 96.48 Very High Very High Very High
Pain 93 90.56 High High
Cancer 67 89.40 High High
Pulmonary Hypertension 85 82.36 Quite High
Injury 4 81.64 Quite High
Ductal Carcinoma 1 67.44 Quite High
Malignant Neoplastic Disease 2 64.44 Quite High
Adhesions 7 59.00 Quite High
Breast Cancer 23 50.00 Quite Low
Calcification 1 32.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Left branch shows distinctive underexpression and loss of expression areas with genes such as IFNGR2, interleukin 2, laminin B1, MSH2, MSH6 CASP8 and 10, RB1, PCNA, EGFR and PGS2, among others, and a few overexpressed genes such as MIF, CDK 2, 5, and 7, RPSA, JUP and ITGAE.
Negative_regulation (loss) of Gene_expression (expression) of PGS2
1) Confidence 0.33 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.56 Pain Relevance 0.03
is a major inducer of extracellular matrix synthesis and decreases the production of decorin [20].
Negative_regulation (decreases) of Gene_expression (production) of decorin in extracellular matrix
2) Confidence 0.18 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.52 Pain Relevance 0
Hinz et al. [9] showed acetaminophen inhibits COX-2 activity in human blood cells and suppresses PG E2 generation in human blood monocytes.
Negative_regulation (suppresses) of Gene_expression (generation) of PG E2 in blood associated with paracetamol
3) Confidence 0.02 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908220 Disease Relevance 0.38 Pain Relevance 1.50
For example, Swierkosz et al. [15] showed the greatest reduction of PG E2 synthesis was in the lung followed by the spleen and brain.
Negative_regulation (reduction) of Gene_expression (synthesis) of PG E2 in brain
4) Confidence 0.02 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908220 Disease Relevance 0.46 Pain Relevance 1.66
For example, Swierkosz et al. [15] showed the greatest reduction of PG E2 synthesis was in the lung followed by the spleen and brain.
Negative_regulation (reduction) of in spleen Gene_expression (synthesis) of PG E2 in brain
5) Confidence 0.01 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908220 Disease Relevance 0.46 Pain Relevance 1.66

General Comments

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