INT185879

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.18
Pain Relevance 6.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDC6) nucleoplasm (CDC6) mitosis (CDC6)
nucleus (CDC6) cell division (CDC6) cytoplasm (CDC6)
Anatomy Link Frequency
H69 1
TEK 1
CDC6 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 6 100.00 Very High Very High Very High
qutenza 910 99.68 Very High Very High Very High
Inflammation 36 70.96 Quite High
Pain 7 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Neuropathic pain 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 436 99.04 Very High Very High Very High
Small Cell Lung Cancer 441 96.08 Very High Very High Very High
Apoptosis 82 84.12 Quite High
INFLAMMATION 36 70.96 Quite High
Disease 25 64.16 Quite High
Lung Cancer 70 57.76 Quite High
Ductal Carcinoma 1 56.92 Quite High
Body Weight 14 56.48 Quite High
Malignant Neoplastic Disease 11 53.92 Quite High
Breast Cancer 61 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PLXDC1, FBXL20, MED1, CRKRS and STARD3 were identified as frequent centromeric borders and IKZF3, PSMD3, THRA, WIPF2, CDC6 and RARA as frequent telomeric borders.
Gene_expression (borders) of CDC6
1) Confidence 0.39 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.42 Pain Relevance 0.16
On the other hand, right branch shows overexpression areas with genes such as CASP 10, CD30-L, and CD-40-L (TNF family), ras-like small, FGF 3 and 5, TDGF1, ERK5, MIF, IFNGR2, MIG, IFN-alpha, beta, gamma, IL-3, -4, -9 and -13, IP-10, HPRT, DCC, TEK, netrin-2, cadherins 4, 8, 12 and 13 [33], MMP3, 8, 10, 12 and 13 (metalloproteinase), COL11A2, CCNG1, CDC-6, ATM, N-MYC, and p53.
Gene_expression (overexpression) of CDC-6 in TEK associated with metalloproteinase
2) Confidence 0.38 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.90 Pain Relevance 0.05
Taken together, capsaicin suppressed the expression of cyclin E, TS, cdc25A and cdc6 both at mRNA and protein levels in human SCLCs.


Gene_expression (expression) of cdc6 associated with qutenza
3) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.56 Pain Relevance 0.93
Furthermore, capsaicin-induced growth arrest was associated with a decrease in the expression of the E2F target genes cyclin E, TS, cdc25A and cdc6.
Gene_expression (expression) of cdc6 associated with qutenza
4) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.71 Pain Relevance 0.94
Western blotting analysis of tumor lysates showed that H69 tumors isolated from capsaicin treated mice had lower levels of cyclin E, TS, cdc25A and cdc6, as compared to control untreated mice (Fig. 3, F).
Gene_expression (levels) of cdc6 in H69 associated with qutenza and cancer
5) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.99 Pain Relevance 0.73
Our results showed that serum-stimulated expression of cyclin E, TS, cdc25A, and cdc6 was significantly down-regulated by 50 ┬ÁM capsaicin (P<01; Fig. 2, A).
Gene_expression (expression) of cdc6 associated with qutenza
6) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.16 Pain Relevance 0.99
We found that the anti-proliferative activity of capsaicin is correlated with a decrease in the expression of E2F-responsive proliferative genes like cyclin E, thymidylate synthase, cdc25A and cdc6, both at mRNA and protein levels.
Gene_expression (expression) of cdc6 associated with qutenza
7) Confidence 0.27 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2857654 Disease Relevance 0.66 Pain Relevance 0.91
We selected cyclin E, TS, cdc25A and cdc6.
Gene_expression (selected) of cdc6
8) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.15 Pain Relevance 0.86
We found that the anti-proliferative activity of capsaicin is correlated with a decrease in the expression of E2F-responsive proliferative genes like cyclin E, thymidylate synthase, cdc25A and cdc6, both at mRNA and protein levels.
Gene_expression (protein) of cdc6 associated with qutenza
9) Confidence 0.27 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2857654 Disease Relevance 0.63 Pain Relevance 0.89

General Comments

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