INT185886

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 15.41
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JUP) cell morphogenesis (JUP) structural molecule activity (JUP)
plasma membrane (JUP) cytoskeleton (JUP) nucleus (JUP)
Anatomy Link Frequency
colon 1
brain 1
neural 1
JUP (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 16 94.96 High High
agonist 29 90.24 High High
Nicotine 9 89.44 High High
Inflammation 71 58.08 Quite High
interstitial cystitis 6 54.72 Quite High
depression 29 44.32 Quite Low
Neuropathic pain 1 43.36 Quite Low
Pain 8 40.00 Quite Low
Central nervous system 19 35.68 Quite Low
Hippocampus 11 30.80 Quite Low
Disease Link Frequency Relevance Heat
Microsatellite Instability 48 100.00 Very High Very High Very High
Adhesions 15 100.00 Very High Very High Very High
Disease 210 99.84 Very High Very High Very High
Neuroblastoma 152 99.64 Very High Very High Very High
Chondrosarcoma 4 99.56 Very High Very High Very High
Cancer 581 99.08 Very High Very High Very High
Hyperplasia 21 99.00 Very High Very High Very High
Chordoma 131 98.52 Very High Very High Very High
Pheochromocytoma 99 98.04 Very High Very High Very High
Apoptosis 148 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-catenin expression through regulation of COX-2 or vice versa.
Gene_expression (expression) of catenin
1) Confidence 0.75 Published 2010 Journal Nutr J Section Body Doc Link PMC2868780 Disease Relevance 0.38 Pain Relevance 0
-catenin expression.
Gene_expression (expression) of catenin
2) Confidence 0.75 Published 2010 Journal Nutr J Section Body Doc Link PMC2868780 Disease Relevance 0.45 Pain Relevance 0
-catenin expressed in HEK293 cells but not a mutant ?
Gene_expression (expressed) of catenin
3) Confidence 0.75 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2667352 Disease Relevance 0 Pain Relevance 0
Although Amitay et al. (2001) reported reduced expression of CTNNG in 9/20 neuroblastoma tumours, we observed promoter methylation in only 11% of neuroblastoma tumours and did not detect promoter methylation in the cell lines that demonstrated an increase expression of CTNNG after 5-aza-dC treatment.
Gene_expression (expression) of CTNNG associated with neuroblastoma and cancer
4) Confidence 0.66 Published 2008 Journal Endocrine-Related Cancer Section Body Doc Link PMC2519165 Disease Relevance 1.84 Pain Relevance 0
Although Amitay et al. (2001) reported reduced expression of CTNNG in 9/20 neuroblastoma tumours, we observed promoter methylation in only 11% of neuroblastoma tumours and did not detect promoter methylation in the cell lines that demonstrated an increase expression of CTNNG after 5-aza-dC treatment.
Gene_expression (expression) of CTNNG associated with neuroblastoma and cancer
5) Confidence 0.66 Published 2008 Journal Endocrine-Related Cancer Section Body Doc Link PMC2519165 Disease Relevance 1.73 Pain Relevance 0
-catenin protein at the cell-to-cell borders but an over-expression in the cytoplasm of the G1 tissues.
Gene_expression (expression) of catenin
6) Confidence 0.65 Published 2010 Journal Nutr J Section Body Doc Link PMC2868780 Disease Relevance 0.29 Pain Relevance 0
-catenin in the normal colon mucosa is too low to be detected by this method of immunohistochemistry (IHC).
Gene_expression (detected) of catenin in colon
7) Confidence 0.65 Published 2010 Journal Nutr J Section Body Doc Link PMC2868780 Disease Relevance 0.53 Pain Relevance 0
-catenin, KRAS, and MSI are present, with PTEN inactivation occuring in about 50% of the cases.
Gene_expression (present) of catenin associated with microsatellite instability
8) Confidence 0.65 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.69 Pain Relevance 0
-catenin signaling pathway, aryl hydrocarbon receptor signaling (cell cycle and apoptosis or nuclear receptor signaling), LPS/IL-1 mediated inhibition of RXR function (nuclear receptor signaling) as well as various metabolic pathways (i.e.
Gene_expression (signaling) of catenin associated with apoptosis
9) Confidence 0.65 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.79 Pain Relevance 0
-catenin was also enriched in the P2 and PSD1 fractions of rat brain (Fig. 6C).
Gene_expression (enriched) of catenin in brain
10) Confidence 0.65 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2667352 Disease Relevance 0 Pain Relevance 0
-catenin levels are markedly reduced in AD patients carrying presenilin-1 (PS-1) inherited mutations [29].
Gene_expression (levels) of catenin associated with disease
11) Confidence 0.65 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.79 Pain Relevance 0
-catenin signaling, including the activation of M1 muscarinic receptor and PKC, the use of Ibuprofen-ChE bi-functional compounds, PPAR ?
Gene_expression (signaling) of catenin
12) Confidence 0.65 Published 2008 Journal Mol Neurodegener Section Abstract Doc Link PMC2515306 Disease Relevance 0.52 Pain Relevance 0.09
-catenin levels.
Gene_expression (levels) of catenin
13) Confidence 0.65 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 1.12 Pain Relevance 0
-catenin expression and mean ranks by Kruskal-Wallis test are shown in Table 2.
Gene_expression (expression) of catenin
14) Confidence 0.58 Published 2010 Journal Nutr J Section Body Doc Link PMC2868780 Disease Relevance 0.43 Pain Relevance 0
-catenin expression compared to G1.
Gene_expression (expression) of catenin
15) Confidence 0.58 Published 2010 Journal Nutr J Section Body Doc Link PMC2868780 Disease Relevance 0.25 Pain Relevance 0.06
Infrequent, or absent, promoter methylation was found for CTNNG (?
Neg (absent) Gene_expression (found) of CTNNG
16) Confidence 0.57 Published 2008 Journal Endocrine-Related Cancer Section Body Doc Link PMC2519165 Disease Relevance 1.72 Pain Relevance 0
Left branch shows distinctive underexpression and loss of expression areas with genes such as IFNGR2, interleukin 2, laminin B1, MSH2, MSH6 CASP8 and 10, RB1, PCNA, EGFR and PGS2, among others, and a few overexpressed genes such as MIF, CDK 2, 5, and 7, RPSA, JUP and ITGAE.
Gene_expression (overexpressed) of JUP
17) Confidence 0.43 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.59 Pain Relevance 0.04
Left branch shows distinctive underexpression and loss of expression areas with genes such as IFNGR2, interleukin 2, laminin B1, MSH2, MSH6 CASP8 and 10, RB1, PCNA, EGFR and PGS2, among others, and a few overexpressed genes such as MIF, CDK 2, 5, and 7, RPSA, JUP and ITGAE.
Gene_expression (expression) of JUP
18) Confidence 0.43 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.62 Pain Relevance 0.04
-catenin, and p53 protein expression, plus Akt, GSK-3?
Gene_expression (ein expres) of catenin
19) Confidence 0.26 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC3020166 Disease Relevance 0.20 Pain Relevance 0.10
The expression of cell adhesion molecules (CAMs) including E-cadherin, alpha-catenin, beta-catenin, gamma-catenin and neural cell adhesion molecule (NCAM) has been associated with formation and maintenance of chordoma tissue architecture and found of diagnostic value for discriminating chordoma from chondrosarcoma, along with the cytokeratins [89,90].
Gene_expression (expression) of gamma-catenin in neural associated with chondrosarcoma, chordoma and adhesions
20) Confidence 0.03 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837065 Disease Relevance 1.47 Pain Relevance 0

General Comments

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