INT185887

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Context Info
Confidence 0.24
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.22
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BCL2) cell morphogenesis (BCL2) endoplasmic reticulum (BCL2)
intracellular (BCL2) cytoplasm (BCL2) cytosol (BCL2)
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 26 27.52 Quite Low
cytokine 11 23.52 Low Low
COX-2 inhibitor 52 5.00 Very Low Very Low Very Low
cINOD 17 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
metalloproteinase 7 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 189 100.00 Very High Very High Very High
Death 38 92.20 High High
Lymphatic System Cancer 6 67.72 Quite High
Stress 6 64.64 Quite High
Cancer 188 52.72 Quite High
Parkinson's Disease 1 52.44 Quite High
Breast Cancer 28 50.00 Quite Low
INFLAMMATION 28 27.52 Quite Low
Fever 41 5.00 Very Low Very Low Very Low
Colon Cancer 23 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, mutation of the Bik phosphorylation sites, in which the Thr and Ser residues were changed to alanine residues, reduced the apoptotic activity of Bik protein without significantly affecting its ability to heterodimerize with BCL-2 [44]
Neg (without) Regulation (affecting) of BCL-2 Binding (heterodimerize) of associated with apoptosis
1) Confidence 0.24 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 1.07 Pain Relevance 0
The interaction between Bax/Bak and the Bcl-2 family anti-apoptotic members is carefully regulated by the BH-3-only proteins.
Regulation (regulated) of Bcl-2 Binding (interaction) of associated with apoptosis
2) Confidence 0.11 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.15 Pain Relevance 0

General Comments

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