INT185888

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Context Info
Confidence 0.52
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 4.98
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RPSA) structural constituent of ribosome (RPSA) ribosome (RPSA)
cell adhesion (RPSA) plasma membrane (RPSA) nucleus (RPSA)
RPSA (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 126 100.00 Very High Very High Very High
Pain 106 97.24 Very High Very High Very High
backache 6 95.56 Very High Very High Very High
COX-2 inhibitor 13 94.96 High High
rheumatoid arthritis 60 89.64 High High
alcohol 6 77.56 Quite High
metalloproteinase 14 73.36 Quite High
cytokine 42 70.20 Quite High
Dopamine 2 69.20 Quite High
Serotonin 2 68.68 Quite High
Disease Link Frequency Relevance Heat
Depression 150 100.00 Very High Very High Very High
Gastrointestinal Disease 1 99.84 Very High Very High Very High
Pain 114 97.24 Very High Very High Very High
Cancer 148 96.60 Very High Very High Very High
Low Back Pain 16 95.56 Very High Very High Very High
Adhesions 4 89.76 High High
Rheumatoid Arthritis 64 89.64 High High
Obesity 10 86.80 High High
Stress 26 79.60 Quite High
Hepatitis 2 78.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, these transcripts covered such diverse proteins and functions as: ribosomal components (LAMR1, MRPL22, RPL35, RPS16, RPS28), which may suggest the existence of a TNF?
Gene_expression (components) of LAMR1
1) Confidence 0.52 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779405 Disease Relevance 0.17 Pain Relevance 0
Left branch shows distinctive underexpression and loss of expression areas with genes such as IFNGR2, interleukin 2, laminin B1, MSH2, MSH6 CASP8 and 10, RB1, PCNA, EGFR and PGS2, among others, and a few overexpressed genes such as MIF, CDK 2, 5, and 7, RPSA, JUP and ITGAE.
Gene_expression (overexpressed) of RPSA
2) Confidence 0.47 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.59 Pain Relevance 0.04
Left branch shows distinctive underexpression and loss of expression areas with genes such as IFNGR2, interleukin 2, laminin B1, MSH2, MSH6 CASP8 and 10, RB1, PCNA, EGFR and PGS2, among others, and a few overexpressed genes such as MIF, CDK 2, 5, and 7, RPSA, JUP and ITGAE.
Gene_expression (expression) of RPSA
3) Confidence 0.47 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.62 Pain Relevance 0.04
Both PRNP and LAMR1 are known to be overexpressed in gastrointestinal disease (Cioce et al 1991; Liang et al 2006), consistent with a tumor-inhibiting APHS effect.
Gene_expression (overexpressed) of LAMR1 associated with gastrointestinal disease and cancer
4) Confidence 0.31 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721360 Disease Relevance 0.81 Pain Relevance 0.05
-dependent expression of the CXCL5, CYP3A4, LAMR1, MCP, and PSMB9 genes, as noted here, has been previously described [35-40].
Gene_expression (expression) of LAMR1
5) Confidence 0.20 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779405 Disease Relevance 0.23 Pain Relevance 0.09
Our hypothesis was that patients with both cLBP and depression display higher TNF?
Gene_expression (depression) of cLBP associated with depression
6) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991021 Disease Relevance 1.49 Pain Relevance 1.10
in the development of both disorders, and may provide a suggestion for the physicians - who should carefully evaluate patients presenting with either cLBP or depressive symptoms and tailor their treatment accordingly.
Gene_expression (presenting) of cLBP associated with depression
7) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991021 Disease Relevance 1.07 Pain Relevance 0.69

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