INT185898

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.36
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP10) extracellular space (MMP10) extracellular region (MMP10)
proteinaceous extracellular matrix (MMP10)
Anatomy Link Frequency
endothelial cells 2
MMP10 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 184 100.00 Very High Very High Very High
Inflammation 60 100.00 Very High Very High Very High
chemokine 4 89.72 High High
Angina 24 87.76 High High
COX-2 inhibitor 38 79.48 Quite High
Opioid 1 74.56 Quite High
imagery 39 50.00 Quite Low
agonist 1 41.12 Quite Low
antagonist 2 40.52 Quite Low
cytokine 16 5.40 Low Low
Disease Link Frequency Relevance Heat
Atherosclerosis 63 100.00 Very High Very High Very High
INFLAMMATION 61 100.00 Very High Very High Very High
Adhesions 20 100.00 Very High Very High Very High
Lymphatic System Cancer 4 99.36 Very High Very High Very High
Leukemia 1 94.56 High High
Apoptosis 58 92.92 High High
Coronary Artery Disease 33 92.04 High High
Breast Cancer 136 91.60 High High
Metastasis 46 90.60 High High
Diabetes Mellitus 3 90.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MMP10 Matrix metalloproteinase 10
Gene_expression (metalloproteinase) of MMP10 associated with metalloproteinase
1) Confidence 0.49 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.52 Pain Relevance 0.36
CRP increased the expression of MMP-1 (collagenase) and MMP-10 (stromelysin-2) by human endothelial cells via kinase pathways.
Gene_expression (expression) of MMP-10 in endothelial cells
2) Confidence 0.48 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716784 Disease Relevance 0.76 Pain Relevance 0.24
CRP increased the expression of MMP-1 (collagenase) and MMP-10 (stromelysin-2) by human endothelial cells via kinase pathways.
Gene_expression (expression) of stromelysin-2 in endothelial cells
3) Confidence 0.48 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716784 Disease Relevance 0.76 Pain Relevance 0.24
Overexpression of MMP10 in transfected lymphoma cells has been shown to stimulate invasive activity in vitro and promote thymic lymphoma growth in an in vivo murine model [19].
Gene_expression (Overexpression) of MMP10 associated with lymphatic system cancer
4) Confidence 0.42 Published 2005 Journal Genome Biol Section Body Doc Link PMC1242209 Disease Relevance 1.08 Pain Relevance 0.09
Recently, we demonstrated that MMP-10 (stromelysin-2) is associated with inflammation and subclinical atherosclerosis, and is also present in atherosclerotic lesions (27).
Gene_expression (present) of stromelysin-2 associated with inflammation and atherosclerosis
5) Confidence 0.37 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716784 Disease Relevance 1.48 Pain Relevance 0.37
Some pro-angiogenic factors (IL18, IL15, MMP10, MMP28) as well as cell adhesion molecules (CEACAM 1, CEACAM 5, CEACAM 6) were also overexpressed.
Gene_expression (overexpressed) of MMP10 associated with adhesions
6) Confidence 0.30 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 0.37 Pain Relevance 0
This is consistent with EIA results, when active MMP-10 was not detected in the media.
Neg (not) Gene_expression (detected) of MMP-10 associated with metalloproteinase
7) Confidence 0.09 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1559713 Disease Relevance 0 Pain Relevance 0.73
In contrast, MMP-9 and MMP-10 were undetectable in the media of Hs578T cells, suggesting that the cells did not secrete these MMPs.
Gene_expression (undetectable) of MMP-10 associated with metalloproteinase
8) Confidence 0.08 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1559713 Disease Relevance 0.39 Pain Relevance 0.65

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