INT185900

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.39
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RPSA) structural constituent of ribosome (RPSA) ribosome (RPSA)
cell adhesion (RPSA) plasma membrane (RPSA) nucleus (RPSA)
RPSA (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 13 94.96 High High
metalloproteinase 6 73.36 Quite High
cINOD 7 5.00 Very Low Very Low Very Low
COX2 3 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Opioid 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gastrointestinal Disease 1 99.84 Very High Very High Very High
Cancer 70 96.60 Very High Very High Very High
Rheumatoid Arthritis 4 86.16 High High
Stress 3 74.12 Quite High
Colon Cancer 26 72.04 Quite High
Ductal Carcinoma 1 61.28 Quite High
Malignant Neoplastic Disease 3 58.28 Quite High
Breast Cancer 23 50.00 Quite Low
Stomach Cancer 1 33.12 Quite Low
Apoptosis 39 32.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Left branch shows distinctive underexpression and loss of expression areas with genes such as IFNGR2, interleukin 2, laminin B1, MSH2, MSH6 CASP8 and 10, RB1, PCNA, EGFR and PGS2, among others, and a few overexpressed genes such as MIF, CDK 2, 5, and 7, RPSA, JUP and ITGAE.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of RPSA
1) Confidence 0.36 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.59 Pain Relevance 0.04
Both PRNP and LAMR1 are known to be overexpressed in gastrointestinal disease (Cioce et al 1991; Liang et al 2006), consistent with a tumor-inhibiting APHS effect.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of LAMR1 associated with gastrointestinal disease and cancer
2) Confidence 0.20 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721360 Disease Relevance 0.81 Pain Relevance 0.05

General Comments

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