INT185901

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Context Info
Confidence 0.55
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.38
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP8) peptidase activity (CASP8) mitochondrion (CASP8)
nucleolus (CASP8) cytoskeleton (CASP8) nucleus (CASP8)
Anatomy Link Frequency
cleavage 2
CASP8 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 49 87.80 High High
midbrain 11 50.00 Quite Low
agonist 57 43.92 Quite Low
chemokine 2 29.36 Quite Low
metalloproteinase 6 7.04 Low Low
Inflammation 11 5.00 Very Low Very Low Very Low
Substantia nigra 9 5.00 Very Low Very Low Very Low
cINOD 7 5.00 Very Low Very Low Very Low
qutenza 6 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 513 100.00 Very High Very High Very High
Death 112 98.80 Very High Very High Very High
Lymphatic System Cancer 6 92.76 High High
Ataxia 1 85.64 High High
Breast Cancer 40 80.96 Quite High
Necrosis 8 76.72 Quite High
Cancer 337 76.36 Quite High
Colon Cancer 66 73.20 Quite High
Pox Virus Infection 19 50.00 Quite Low
Stress 6 35.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CASP8 Apoptotic cysteine protease MCH5
Localization (protease) of CASP8 associated with apoptosis
1) Confidence 0.55 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.93 Pain Relevance 0.09
Membranes were blocked with 5% milk in TBS containing 0.1% Tween 20, and incubated with antibodies specific for caspase 8 (Abcam), caspase 9, PARP, Snail (Cell Signaling Technology), pGSK3?
Localization (caspase) of caspase 8
2) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 0.26 Pain Relevance 0
protein (c-FLIP), an inactive homolog of caspase-8, primarily functions as an
Localization (homolog) of caspase-8
3) Confidence 0.12 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.51 Pain Relevance 0
caspase-8-mediated cleavage of Bid, which facilitates Bax activation and
Localization (cleavage) of caspase-8 in cleavage
4) Confidence 0.12 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.31 Pain Relevance 0
The antibodies against caspase3, caspase8, caspase9, DR5, Bcl-2, Bax and ?
Localization (caspase9) of caspase8
5) Confidence 0.09 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2941086 Disease Relevance 0 Pain Relevance 0
There was no gross difference in proteolytic cleavage of caspase-8 into its active p43/p41 and p18 fragments between both cell lines after 2, 4, and 6 h (Figure 6C).
Localization (cleavage) of caspase-8 in cleavage
6) Confidence 0.07 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.67 Pain Relevance 0
In contrast, we identified almost no cells double positive for HNuc/cleaved caspase-8 (Figure 4D) and HNuc/BAX (Figure 4E) in cultures treated with FGF-20.
Localization (cleaved) of caspase-8
7) Confidence 0.06 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525922 Disease Relevance 0.70 Pain Relevance 0

General Comments

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