INT185908

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.71
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 6.18
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL11A1) cell adhesion (COL11A1) protein binding, bridging (COL11A1)
extracellular matrix organization (COL11A1)
Anatomy Link Frequency
stellate cells 2
eye 1
fat 1
epithelial cell 1
COL11A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 95.12 Very High Very High Very High
chemokine 6 76.88 Quite High
Inflammation 110 50.00 Quite Low
Chronic pancreatitis 45 36.16 Quite Low
metalloproteinase 6 23.84 Low Low
cytokine 10 8.72 Low Low
alcohol 5 6.32 Low Low
fibrosis 10 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cirrhosis 230 99.80 Very High Very High Very High
Cancer 294 99.62 Very High Very High Very High
Primary Sclerosing Cholangitis 155 99.06 Very High Very High Very High
Pain 2 95.12 Very High Very High Very High
Stress 3 94.32 High High
Syndrome 5 91.28 High High
Disease 78 88.24 High High
Ductal Carcinoma 1 87.00 High High
Malignant Neoplastic Disease 7 84.00 Quite High
Adhesions 22 83.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During embryogenesis, Col11a1 expression is also detectable in many other human fetal tissues including the bone [40].
Gene_expression (expression) of Col11a1
1) Confidence 0.71 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.04 Pain Relevance 0
Since there was no suitable antibody for immunoblot analysis, the expression of Col11a1 in tissues and in cultured stellate cells was evaluated by immunohistochemistry and immunocytochemistry.
Gene_expression (expression) of Col11a1 in stellate cells
2) Confidence 0.71 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 0.79 Pain Relevance 0
Col11a1 is mainly expressed in articular cartilage and the vitreous fluid of the eye [39-43].
Gene_expression (expressed) of Col11a1 in eye
3) Confidence 0.71 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.14 Pain Relevance 0
Verification of Col11a1 protein expression in cultured stellate cells by immunocytochemistry showed also a PSC specific staining (Figure 6).


Gene_expression (expression) of Col11a1 in stellate cells associated with primary sclerosing cholangitis
4) Confidence 0.55 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.29 Pain Relevance 0.04
In all patients, PSC showed a specific staining while HSC remained Col11a1 negative by immunohistochemistry.
Neg (negative) Gene_expression (negative) of Col11a1 associated with cirrhosis and primary sclerosing cholangitis
5) Confidence 0.55 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.02 Pain Relevance 0.03
We used average cluster linkage, uncentered [31] based on Euclidean distance and removed all genes that were turned on in tumors but that were not expressed in normal tissue (NCK5AI, CDK5 activator, CDC25A, ERK4, K2P, COL11A1, OBCAM, AMPHIREGULIN, BCGF1 and BMP8).
Neg (not) Gene_expression (expressed) of COL11A1 associated with cancer
6) Confidence 0.53 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.54 Pain Relevance 0
Significantly differentially expressed genes represent proteins with diverse functions: extracellular matrix proteins (Col11A1, tenascin xb), proteins involved in bone, fat and epithelial cell metabolism (osteoprotegerin, b219ob receptor, FGF- 7), pain perception and stress response (proenkephalin), growth-promoting activity (IGF-2), and signaling and cell survival mechanisms (semaphorin 3c).
Gene_expression (expressed) of Col11A1 in epithelial cell associated with stress and pain
7) Confidence 0.41 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.19 Pain Relevance 0.10
Significantly differentially expressed genes represent proteins with diverse functions: extracellular matrix proteins (Col11A1, tenascin xb), proteins involved in bone, fat and epithelial cell metabolism (osteoprotegerin, b219ob receptor, FGF- 7), pain perception and stress response (proenkephalin), growth-promoting activity (IGF-2), and signaling and cell survival mechanisms (semaphorin 3c).
Gene_expression (expressed) of Col11A1 in fat associated with stress and pain
8) Confidence 0.14 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.19 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox