INT185909

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Context Info
Confidence 0.24
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.63
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BCL2) cell morphogenesis (BCL2) endoplasmic reticulum (BCL2)
intracellular (BCL2) cytoplasm (BCL2) cytosol (BCL2)
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 7 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Opioid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 75 100.00 Very High Very High Very High
Death 13 97.44 Very High Very High Very High
Lymphatic System Cancer 2 87.04 High High
Pancreatic Cancer 48 84.20 Quite High
Parkinson's Disease 1 71.76 Quite High
Breast Cancer 24 50.00 Quite Low
Starvation 15 34.32 Quite Low
Stress 18 31.60 Quite Low
Cancer 82 16.88 Low Low
Adhesions 8 16.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The phosphorylation state of anti-apoptotic (Bcl-2 and Bcl-xL) and pro-apoptotic (Bad, Bid and Bik) Bcl-2 proteins regulates their cellular activity and, therefore, cell survival and cell death.
Regulation (regulates) of Phosphorylation (phosphorylation) of Bcl-2 associated with apoptosis and death
1) Confidence 0.24 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 1.00 Pain Relevance 0
(E) Vitamin E has no effect on Bcl-2 phosphorylation.
Neg (no) Regulation (effect) of Phosphorylation (phosphorylation) of Bcl-2
2) Confidence 0.05 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2916709 Disease Relevance 0 Pain Relevance 0
Compared with parental cells and vector cells, clone 2 and pool 1 cells transfected with pcDNA3.1-FRNK showed a decrease in survivin expression and Bad phosphorylation at Ser136 but did not affect Bax, Bcl-2 or Bad expression or Bad phosphorylation at Ser112 (Fig. 5E).
Neg (not) Regulation (affect) of Phosphorylation (phosphorylation) of Bcl-2
3) Confidence 0.03 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.63 Pain Relevance 0

General Comments

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