INT18591

Context Info Confidence 0.12 First Reported 1983 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 0.73 Pain Relevance 3.48

oxidoreductase activity (Fdft1) endoplasmic reticulum (Fdft1) transferase activity, transferring alkyl or aryl (other than methyl) groups (Fdft1)

Anatomy Link Frequency brain 2 nociceptors 2 Fdft1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Somatostatin 59 100.00 Calcitonin gene-related peptide 32 100.00 substance P 29 100.00 nociceptor 4 99.90 unmyelinated 1 99.66 Neuropeptide 11 96.72 Dorsal horn 5 95.16 tetrodotoxin 3 93.52 projection neuron 1 92.36 Calcium channel 2 90.84

Disease Link Frequency Relevance Heat Nociception 25 93.92 Pain 23 76.24 Stress 12 56.56 Hyperalgesia 1 46.80 Polycystic Ovary Syndrome 7 5.00 Urological Neuroanatomy 3 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Cultured cells exhibit a measurable basal secretion of immunoactive SS (SSLI) which can be augmented by carbachol, acetylcholine, or oxotremorine.

Positive_regulation (augmented) of Localization (secretion) of SS associated with somatostatin

1) Confidence 0.12 Published 1983 Journal Endocrinology Section Abstract Doc Link 6129132 Disease Relevance 0 Pain Relevance 0.61

Cysteamine, which has been reported to deplete SS content and to increase SS release in brain, augmented the basal and evoked release of ACh from hippocampal slices, without affecting SS-like content and release.

Positive_regulation (increase) of Localization (release) of SS in brain associated with somatostatin

2) Confidence 0.11 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 1976754 Disease Relevance 0 Pain Relevance 1.34

In particular, activation of alpha 2-adrenoceptors stimulates GH secretion via endogenous GHRH release, although a mechanism operating to inhibit hypothalamic SS release cannot be excluded; stimulation of alpha 1-adrenoceptors is inhibitory to GH secretion exclusively via an increased release of hypothalamic SS.

Positive_regulation (increased) of Localization (release) of SS associated with somatostatin

3) Confidence 0.04 Published 1987 Journal Endocrinology Section Abstract Doc Link 2881775 Disease Relevance 0 Pain Relevance 0.31

After peripheral noxious stimulation of unmyelinated nociceptors the release of calcitonin gene-related peptide (CGRP) [7], substance P (SP) [8] and somatostatin (SS) [4,9] is increased although it remains largely unchanged after innocuous stimulation or stimulation of large myelinated fibres [8,9].

Positive_regulation (increased) of Localization (release) of SS in nociceptors associated with nociceptor, somatostatin, unmyelinated, substance p and calcitonin gene-related peptide

4) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2727498 Disease Relevance 0.73 Pain Relevance 1.21

General Comments

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