INT18591

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Context Info
Confidence 0.12
First Reported 1983
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.73
Pain Relevance 3.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Fdft1) endoplasmic reticulum (Fdft1) transferase activity, transferring alkyl or aryl (other than methyl) groups (Fdft1)
Anatomy Link Frequency
brain 2
nociceptors 2
Fdft1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 59 100.00 Very High Very High Very High
Calcitonin gene-related peptide 32 100.00 Very High Very High Very High
substance P 29 100.00 Very High Very High Very High
nociceptor 4 99.90 Very High Very High Very High
unmyelinated 1 99.66 Very High Very High Very High
Neuropeptide 11 96.72 Very High Very High Very High
Dorsal horn 5 95.16 Very High Very High Very High
tetrodotoxin 3 93.52 High High
projection neuron 1 92.36 High High
Calcium channel 2 90.84 High High
Disease Link Frequency Relevance Heat
Nociception 25 93.92 High High
Pain 23 76.24 Quite High
Stress 12 56.56 Quite High
Hyperalgesia 1 46.80 Quite Low
Polycystic Ovary Syndrome 7 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cultured cells exhibit a measurable basal secretion of immunoactive SS (SSLI) which can be augmented by carbachol, acetylcholine, or oxotremorine.
Positive_regulation (augmented) of Localization (secretion) of SS associated with somatostatin
1) Confidence 0.12 Published 1983 Journal Endocrinology Section Abstract Doc Link 6129132 Disease Relevance 0 Pain Relevance 0.61
Cysteamine, which has been reported to deplete SS content and to increase SS release in brain, augmented the basal and evoked release of ACh from hippocampal slices, without affecting SS-like content and release.
Positive_regulation (increase) of Localization (release) of SS in brain associated with somatostatin
2) Confidence 0.11 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 1976754 Disease Relevance 0 Pain Relevance 1.34
In particular, activation of alpha 2-adrenoceptors stimulates GH secretion via endogenous GHRH release, although a mechanism operating to inhibit hypothalamic SS release cannot be excluded; stimulation of alpha 1-adrenoceptors is inhibitory to GH secretion exclusively via an increased release of hypothalamic SS.
Positive_regulation (increased) of Localization (release) of SS associated with somatostatin
3) Confidence 0.04 Published 1987 Journal Endocrinology Section Abstract Doc Link 2881775 Disease Relevance 0 Pain Relevance 0.31
After peripheral noxious stimulation of unmyelinated nociceptors the release of calcitonin gene-related peptide (CGRP) [7], substance P (SP) [8] and somatostatin (SS) [4,9] is increased although it remains largely unchanged after innocuous stimulation or stimulation of large myelinated fibres [8,9].
Positive_regulation (increased) of Localization (release) of SS in nociceptors associated with nociceptor, somatostatin, unmyelinated, substance p and calcitonin gene-related peptide
4) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2727498 Disease Relevance 0.73 Pain Relevance 1.21

General Comments

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