INT185927

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2010
Negated 1
Speculated 4
Reported most in Body
Documents 12
Total Number 16
Disease Relevance 6.35
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (AR) transport (AR) enzyme binding (AR)
DNA binding (AR) cell-cell signaling (AR) cytoplasm (AR)
Anatomy Link Frequency
spinal 2
bladder 2
EPI 2
AR (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 82 99.96 Very High Very High Very High
Central nervous system 4 99.84 Very High Very High Very High
adenocard 213 99.64 Very High Very High Very High
Inflammation 93 99.04 Very High Very High Very High
cytokine 13 98.52 Very High Very High Very High
IPN 18 97.76 Very High Very High Very High
hyperexcitability 10 96.56 Very High Very High Very High
interstitial cystitis 52 96.40 Very High Very High Very High
Catecholamine 11 95.88 Very High Very High Very High
agonist 213 93.60 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 177 100.00 Very High Very High Very High
Muscular Atrophy 6 100.00 Very High Very High Very High
Prostate Cancer 268 99.48 Very High Very High Very High
Reprotox - General 1 102 99.48 Very High Very High Very High
INFLAMMATION 132 99.04 Very High Very High Very High
Inflammatory Pain 18 97.76 Very High Very High Very High
Adhesions 4 97.76 Very High Very High Very High
Hypersensitivity 15 96.76 Very High Very High Very High
Interstitial Cystitis 52 96.40 Very High Very High Very High
Disease 73 95.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, lower expression of CCND1 in the therapy-resistant sublines, in particular PC346Flu1 and PC346Flu2, may contribute to the maintenance of AR activity under selection conditions.
Spec (may) Positive_regulation (contribute) of Positive_regulation (maintenance) of AR
1) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0 Pain Relevance 0
Because the effect of VAV3 on cell division and AR activation is dependent on GEF activity, this variant is not oncogenic and has most likely a different function than the full-length protein.
Positive_regulation (dependent) of Positive_regulation (activation) of AR
2) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.43 Pain Relevance 0
Thus, increased AR-HSP dissociation promoted increased AR activation and AR-driven gene expression.
Positive_regulation (promoted) of Positive_regulation (activation) of AR
3) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.14 Pain Relevance 0
This would allow AR activation and AR-driven gene expression at much lower levels of extracellular testosterone signals.
Positive_regulation (allow) of Positive_regulation (activation) of AR
4) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.42 Pain Relevance 0.08
Thus, increased AR-HSP dissociation promoted increased AR activation and AR-driven gene expression.
Positive_regulation (increased) of Positive_regulation (activation) of AR
5) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.14 Pain Relevance 0
Activated AR was modeled as both a transcriptional activator of PSA expression [58] and a transcriptional represser of PAcP expression [20].
Positive_regulation (activator) of Positive_regulation (Activated) of AR
6) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0
Thus, increased AR-HSP dissociation promoted increased AR activation and AR-driven gene expression.
Positive_regulation (increased) of Positive_regulation (activation) of AR
7) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.15 Pain Relevance 0
Thus, increased AR-HSP dissociation promoted increased AR activation and AR-driven gene expression.
Positive_regulation (increased) of Positive_regulation (activation) of AR
8) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.15 Pain Relevance 0
Overall, this data supports increased AR activity in CRPC, which is consistent with re-expression of androgen-regulated genes as previously reported [68] and similarity of expression of androgen regulated genes between CRPC and prostate cancer before androgen ablation [23].


Positive_regulation (supports) of Positive_regulation (increased) of AR associated with reprotox - general 1
9) Confidence 0.16 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2956710 Disease Relevance 0.57 Pain Relevance 0
-AR stimulation may induce expression of iNOS, which would generate higher levels of NO contributing to the production of inflammatory pain and increased micturition associated with IC.
Spec (may) Positive_regulation (induce) of Positive_regulation (stimulation) of AR associated with ipn, overactive bladder and interstitial cystitis
10) Confidence 0.14 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0.99 Pain Relevance 0.63
-AR stimulation in these patients may induce COX-2 and iNOS leading to the increased progression of inflammatory pain and bladder hyperexcitability associated with this disease.
Spec (may) Positive_regulation (induce) of Positive_regulation (stimulation) of AR in bladder associated with ipn, disease and hyperexcitability
11) Confidence 0.14 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0.89 Pain Relevance 0.76
Replacement of the 6-amino group of NECA with the guanidino moiety determined a threefold enhancement in A2B AR activation potency (EC50?
Spec (determined) Positive_regulation (enhancement) of Positive_regulation (activation) of AR associated with potency
12) Confidence 0.10 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0 Pain Relevance 0.35
Fig. 4Schematic overview of the most important structural modifications of adenosine and nonadenosine derivatives for a potent and/or selective activation of the A2B AR



Positive_regulation (derivatives) of Positive_regulation (activation) of AR associated with adenocard
13) Confidence 0.10 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.05 Pain Relevance 0.22
Activation of A2B AR subtype would moreover increase production of the anti-inflammatory cytokine IL-10 [50].
Positive_regulation (increase) of Positive_regulation (Activation) of AR associated with inflammation and cytokine
14) Confidence 0.10 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.88 Pain Relevance 0.41
-AR activation by ISO can activate ERK1/2 at high concentrations, we have observed that ERK1/2 activation by EPI at concentrations that up-regulate GRK3 appears to require the simultaneous activation of both ?
Positive_regulation (activate) of Positive_regulation (activation) of AR in EPI
15) Confidence 0.07 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0
Similar findings were observed in a spinal and bulbar muscular atrophy (SBMA) TG mouse model: oral administration of GGA up-regulated the expression of HSPs in the central nervous system in the SBMA TG mice while no induction was detected in NTG mice [20].
Positive_regulation (detected) of Neg (no) Positive_regulation (induction) of SBMA in spinal associated with targeted disruption, central nervous system and muscular atrophy
16) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.54 Pain Relevance 0.05

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