INT185929

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Context Info
Confidence 0.20
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 1.66
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6) nucleus (IRF6) DNA binding (IRF6)
cytoplasm (IRF6)
Anatomy Link Frequency
monocytes 6
adipocytes 2
IRF6 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 36 99.32 Very High Very High Very High
agonist 53 99.28 Very High Very High Very High
Inflammatory mediators 9 90.40 High High
Inflammation 151 89.84 High High
Kinase C inhibitor 1 85.68 High High
cytokine 50 82.84 Quite High
Inflammatory marker 2 81.04 Quite High
Enkephalin 3 80.44 Quite High
substance P 3 79.80 Quite High
Neurotransmitter 1 70.28 Quite High
Disease Link Frequency Relevance Heat
Obesity 68 99.32 Very High Very High Very High
Sepsis 117 98.56 Very High Very High Very High
INFLAMMATION 197 90.40 High High
Death 9 87.28 High High
Cv General 2 Under Development 5 80.56 Quite High
Lung Injury 13 73.04 Quite High
Pulmonary Edema 2 56.96 Quite High
Interstitial Cystitis 26 56.48 Quite High
Heart Rate Under Development 1 50.52 Quite High
Myalgia 1 49.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specificity of the action of LPS on mature human adipocytes
Regulation (Specificity) of Gene_expression (action) of LPS in adipocytes associated with obesity
1) Confidence 0.20 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.10 Pain Relevance 0.04
in the LPS group is consistent with observations in patients with sepsis, in whom persistent high levels of TNF?
Regulation (consistent) of Gene_expression (group) of LPS associated with sepsis
2) Confidence 0.18 Published 2008 Journal Crit Care Section Body Doc Link PMC2575593 Disease Relevance 0.48 Pain Relevance 0.04
Two of the donors did not yield sufficient monocytes to allow for the particular controls involving AEBSF added only after the 16 h incubation ± LPS, so N = 2 for those particular controls.
Regulation (involving) of Gene_expression (added) of LPS in monocytes
3) Confidence 0.11 Published 2008 Journal Proteome Sci Section Body Doc Link PMC2413206 Disease Relevance 0 Pain Relevance 0
release stimulated by CL075 or prolonged LPS exposure alone using a P2X7 receptor antagonist, we considered whether the IL-1?
Regulation (using) of Gene_expression (exposure) of LPS associated with antagonist
4) Confidence 0.05 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0 Pain Relevance 0.09
release stimulated by CL075 or prolonged LPS exposure alone using a P2X7 receptor antagonist, we considered whether the IL-1?
Regulation (prolonged) of Gene_expression (exposure) of LPS associated with antagonist
5) Confidence 0.05 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0 Pain Relevance 0.09
A recently published ex-vivo laboratory study has also shown that eritoran in doses of 0.03 ng/mL up to 10 ng/mL causes a dose-dependent inhibitory effect on IL-6 and TNF-alfa production in LPS-stimulated human monocytes (Czeslick et al. 2006).


Regulation (effect) of Gene_expression (production) of LPS in monocytes
6) Confidence 0.05 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012437 Disease Relevance 0.35 Pain Relevance 0.04
Maximum expression of COX-2 and iNOS was observed 2 hr after LPS addition, which is similar to the time course observed using isoproterenol.
Regulation (after) of Gene_expression (addition) of LPS
7) Confidence 0.04 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0.72 Pain Relevance 0.46
Thus, we studied the capacity of several microbial products, including agonists of TLR2, TLR4 or NOD2 (Pam3CysSK4, LPS and MDP, respectively), to modulate the expression of HLA-DR on monocytes.
Regulation (modulate) of Gene_expression (expression) of LPS in monocytes associated with agonist
8) Confidence 0.03 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.23
Inhibitory effect of melittin and bee venom on the LPS as well as SNP-induced I?
Regulation (effect) of Gene_expression (venom) of LPS
9) Confidence 0.03 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0 Pain Relevance 0

General Comments

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