INT18593

Context Info Confidence 0.11 First Reported 1990 Last Reported 1995 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.08 Pain Relevance 2.12

extracellular space (Sst) oxidoreductase activity (Fdft1) extracellular region (Sst) endoplasmic reticulum (Fdft1) transferase activity, transferring alkyl or aryl (other than methyl) groups (Fdft1)

Anatomy Link Frequency hippocampus 2 Sst (Rattus norvegicus) Fdft1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Somatostatin 33 100.00 antagonist 3 99.70 Hippocampus 8 99.66 agonist 2 98.68 Clonidine 9 98.02 Neuropeptide 1 91.32 tetrodotoxin 1 78.08 Calcium channel 2 75.40 conotoxin 1 72.12

Disease Link Frequency Relevance Heat Decapitation 1 78.00 Bordatella Infection 1 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The results suggest that in the rat hippocampus, both SS-28 and SS-14 interact with SS receptors to regulate ACh release indirectly by a mechanism that involves alterations of calcium influx during depolarization.

SS-14 Binding (interact) of SS in hippocampus associated with somatostatin and hippocampus

1) Confidence 0.11 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 1976754 Disease Relevance 0 Pain Relevance 1.14

We studied whether clonidine, an alpha 2-adrenoceptor agonist, and yohimbine, an alpha 2-adrenoceptor antagonist, can modulate somatostatin-like immunoreactivity (SSLI) levels, binding of 125I-Tyr11-somatostatin (125I-Tyr11-SS) to its specific receptors, SS-inhibited adenylyl cyclase (AC) activity, and the guanine-nucleotide binding regulatory proteins Gi and G(o) in the rat hippocampus.

somatostatin Binding (binding) of SS in hippocampus associated with antagonist, somatostatin, agonist, hippocampus and clonidine

2) Confidence 0.07 Published 1995 Journal Neuropsychopharmacology Section Abstract Doc Link 7766286 Disease Relevance 0.08 Pain Relevance 0.98

General Comments

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