INT185951

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.84
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (C9) plasma membrane (C9)
Anatomy Link Frequency
neuronal 1
dopamine neurons 1
C9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 36 97.04 Very High Very High Very High
Hippocampus 8 82.48 Quite High
Inflammation 67 73.84 Quite High
Substantia nigra 72 67.92 Quite High
tolerance 3 43.08 Quite Low
cytokine 35 33.96 Quite Low
cINOD 16 7.52 Low Low
Pain 3 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dengue 64 97.76 Very High Very High Very High
Stress 24 96.96 Very High Very High Very High
Disease 272 96.32 Very High Very High Very High
Diabetes Mellitus 6 96.24 Very High Very High Very High
Insulin Resistance 1 94.72 High High
Parkinson's Disease 76 89.32 High High
Injury 20 82.92 Quite High
Alzheimer's Dementia 4 82.36 Quite High
Amyloid Plaque 8 81.76 Quite High
Metabolic Disorder 1 81.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, when patient samples were analyzed the found a strong correlation between NS1 concentration and C5b-C9 complex formation.


Gene_expression (formation) of C9
1) Confidence 0.65 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 0.54 Pain Relevance 0
Although staining for C9 was also used in the study by Yamada et al. [21] and has been used by others to detect the MAC [34-36], C9 immunoreactivity on melanized neurons could indicate late-stage complement activation, upregulation of neuronal C9 synthesis, or both.
Gene_expression (synthesis) of C9 in neuronal
2) Confidence 0.39 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1626447 Disease Relevance 0.99 Pain Relevance 0.16
Immunocytochemical staining for iC3b and C9
Gene_expression (iC3b) of C9
3) Confidence 0.39 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1626447 Disease Relevance 0.99 Pain Relevance 0.03
Immunocytochemical staining for iC3b and C9
Gene_expression (staining) of C9
4) Confidence 0.39 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1626447 Disease Relevance 1.05 Pain Relevance 0.03
Detection of C9 on degenerating melanized neurons suggests that deposition of the MAC on dopamine neurons may reach lytic levels in PD and contribute to the loss of these neurons.
Gene_expression (Detection) of C9 in dopamine neurons associated with dopamine and disease
5) Confidence 0.34 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1626447 Disease Relevance 0.94 Pain Relevance 0.16
The other surface patch is generated using the curves c6, c7, c8, c9 and c10 where the curve c6 is common to both surface patches.
Gene_expression (using) of c9
6) Confidence 0.25 Published 2005 Journal Theor Biol Med Model Section Body Doc Link PMC1198260 Disease Relevance 0.43 Pain Relevance 0
There has been some concern that CLA administration (either the c9, t11 or t10, c12 isomer) could lead to an increase in markers of oxidative stress and that this was responsible for an increase in insulin resistance [33], [59].
Gene_expression (administration) of c9 associated with stress and insulin resistance
7) Confidence 0.09 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994592 Disease Relevance 0.91 Pain Relevance 0.07

General Comments

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