INT185973

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Context Info
Confidence 0.54
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 2.83
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Syp) protein complex (Syp)
Anatomy Link Frequency
hypothalamus 1
molecular layer 1
striatum 1
brain 1
Syp (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 100 99.70 Very High Very High Very High
glial activation 4 98.36 Very High Very High Very High
Catecholamine 31 97.12 Very High Very High Very High
midbrain 27 87.28 High High
Hippocampus 104 83.92 Quite High
Deafferentation 15 77.28 Quite High
Inflammation 80 66.60 Quite High
Thalamus 60 52.80 Quite High
Neuritis 1 52.36 Quite High
Abeta 1 50.00 Quite Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 94 98.92 Very High Very High Very High
Targeted Disruption 739 95.32 Very High Very High Very High
Alzheimer's Dementia 643 95.08 Very High Very High Very High
Cognitive Disorder 125 91.52 High High
Retts Disease 34 83.52 Quite High
Injury 27 76.32 Quite High
Vascular Disease 64 71.28 Quite High
Brain Injury 11 71.16 Quite High
Amyloid Plaque 152 67.44 Quite High
INFLAMMATION 84 66.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings in ASKO mice demonstrated that a loss of a-Syn produced the opposite effect on TH and PP2A imply that enzymatic dysregulation can also occur by a loss of soluble a-Syn, as those mice express normal levels of ?
Negative_regulation (loss) of Syn
1) Confidence 0.54 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.07 Pain Relevance 0.07
To assess the impact of a-Syn loss in vivo, we used striatum from 12-month-old ASKO mice and age-matched Non-Tg controls in which we measured TH phosphorylation, TH activity, and PP2A activity.
Negative_regulation (loss) of Syn in striatum
2) Confidence 0.40 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0.05
Our findings in ASKO mice demonstrated that a loss of a-Syn produced the opposite effect on TH and PP2A imply that enzymatic dysregulation can also occur by a loss of soluble a-Syn, as those mice express normal levels of ?
Negative_regulation (loss) of Syn
3) Confidence 0.40 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.11 Pain Relevance 0.06
-Synuclein (a-Syn), a protein implicated in Parkinson disease, contributes significantly to dopamine metabolism. a-Syn binding inhibits the activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis.
Negative_regulation (inhibits) of Syn associated with parkinson's disease, dopamine and catecholamine
4) Confidence 0.40 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2878529 Disease Relevance 0.10 Pain Relevance 0.13
Synaptophysin and PSD95 were downregulated in the hypothalamus and syntaxin 1a and synaptotagmin were significantly decreased in the cortex of Mecp2?
Negative_regulation (downregulated) of Synaptophysin in hypothalamus
5) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.27 Pain Relevance 0
This reduction in TH-Ser(P)-19 in WT-Syn- and S129A-Syn-transduced SNc suggested that TH activity might also be reduced in a-Syn lentivirally transduced mice.
Negative_regulation (reduction) of Syn
6) Confidence 0.35 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0.12
Two days after lesion, synaptophysin levels as detected by ELISA, declined by 46% in the ipsilateral dentate compared to the contralateral side (p = 0.039) (Fig. 5E).
Negative_regulation (declined) of synaptophysin
7) Confidence 0.28 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1199600 Disease Relevance 0.08 Pain Relevance 0.04
An age-dependent decrease in synaptophysin IR has been documented in the PDAPP mouse line [84].
Negative_regulation (decrease) of synaptophysin
8) Confidence 0.18 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.19 Pain Relevance 0
Some studies report a reproducible loss of synaptophysin IR.
Negative_regulation (loss) of synaptophysin
9) Confidence 0.18 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.22 Pain Relevance 0
Using this method, at two and seven days after lesion, there was greater than a 40% reduction in synaptophysin levels in the OML, a value which at least may closer reflect the absolute loss of fibers after ECL.
Negative_regulation (reduction) of synaptophysin
10) Confidence 0.18 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1199600 Disease Relevance 0 Pain Relevance 0
Two days after ECL, there was a marked decline in synaptophysin immunoreactivity in the OML on the ipsilateral side of the dentate (Fig. 5A), that was reflected by a loss of the typical tri-laminar pattern of synaptophysin staining (Fig. 5B) with only the inner molecular layer clearly distinguishable.
Negative_regulation (decline) of synaptophysin in molecular layer
11) Confidence 0.18 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1199600 Disease Relevance 0.14 Pain Relevance 0.09
deposits and improved the loss of synaptophysin and of MAP2 immunoreactivity.
Negative_regulation (loss) of synaptophysin
12) Confidence 0.16 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 1.03 Pain Relevance 0.24
Some studies reported an absence of change: in the APP23 mouse line, for instance, no loss of synaptophysin IR has been detected despite robust A?
Neg (no) Negative_regulation (loss) of synaptophysin
13) Confidence 0.13 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.44 Pain Relevance 0
Expression levels of synaptophysin were decreased in all brain regions of A?
Negative_regulation (levels) of synaptophysin in brain
14) Confidence 0.09 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.12 Pain Relevance 0.05
Not all of the PrPSc positive structures were synaptophysin positive.
Negative_regulation (positive) of synaptophysin
15) Confidence 0.08 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2825502 Disease Relevance 0.06 Pain Relevance 0.03
As a consistent model, we propose in Meta II an orientation of the 15-anti Schiff base toward the cytoplasmic side of the receptor, away from Glu181, resulting in a low apparent pKA, while the 15-syn Schiff base in active Meta III is oriented toward Glu181, thereby increasing the apparent pKA considerably.
Negative_regulation (oriented) of 15-syn
16) Confidence 0.02 Published 2008 Journal J Mol Biol Section Body Doc Link PMC2726285 Disease Relevance 0 Pain Relevance 0

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