INT185989

Context Info Confidence 0.11 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 2.41 Pain Relevance 0.05

extracellular space (GREM1) extracellular region (GREM1) cell-cell signaling (GREM1)

Anatomy Link Frequency Eustachian tube 1 respiratory 1 GREM1 (Homo sapiens)

Pain Link Frequency Relevance Heat cocaine 8 92.32 Inflammation 24 5.00 cytokine 10 5.00 Inflammatory mediators 8 5.00 cva 4 5.00 Inflammatory response 2 5.00 Earache 2 5.00 addiction 1 5.00 methadone 1 5.00

Disease Link Frequency Relevance Heat Viral Infection 51 99.98 Infection 100 99.50 Hyperplasia 6 99.22 Influenza Virus Infection 46 99.14 Superinfection 6 96.12 Emergencies 11 93.84 Respiratory Syncytial Virus 38 91.40 Thrombosis 2 85.08 Abscess 2 84.48 Hepatitis C Virus Infection 34 73.48

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

These findings raise the question: Would injecting-related harms including BBVI decrease if drug prices increased and availability decreased [13]?

Localization (decrease) of increased associated with viral infection

1) Confidence 0.11 Published 2005 Journal BMC Public Health Section Body Doc Link PMC1199605 Disease Relevance 0.87 Pain Relevance 0.05

Moreover, we observed goblet cell hyperplasia within the Eustachian tube mucosa and increased mucus secretion into the Eustachian tube lumen, which could provide additional means to predispose to bacterial superinfection of the tympanum.

Localization (secretion) of increased in Eustachian tube associated with superinfection and hyperplasia

2) Confidence 0.01 Published 2010 Journal J Leukoc Biol Section Body Doc Link PMC2812561 Disease Relevance 1.08 Pain Relevance 0

Conversely, influenza A virus infection, which also leads to an increased production of respiratory secretions in the 1st week after exposure of human volunteers [107], does indeed alter the character of these respiratory fluids.

Localization (secretions) of increased in respiratory associated with influenza virus infection and infection

3) Confidence 0.01 Published 2010 Journal J Leukoc Biol Section Body Doc Link PMC2812561 Disease Relevance 0.47 Pain Relevance 0

General Comments

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