INT186

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Context Info
Confidence 0.70
First Reported 1977
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 30
Total Number 31
Disease Relevance 5.00
Pain Relevance 5.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Cyp1a1) mitochondrion (Cyp1a1) oxidoreductase activity (Cyp1a1)
aging (Cyp1a1) endoplasmic reticulum (Cyp1a1) enzyme binding (Cyp1a1)
Anatomy Link Frequency
liver 3
MCF-7 2
brain 2
hepatocyte 1
Cyp1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
carbamazepine 1 99.76 Very High Very High Very High
cytokine 1 99.40 Very High Very High Very High
Chronic pancreatitis 6 98.92 Very High Very High Very High
methadone 10 98.30 Very High Very High Very High
ketamine 3 97.82 Very High Very High Very High
tetrodotoxin 8 97.12 Very High Very High Very High
Lamotrigine 1 94.68 High High
Paracetamol 13 94.56 High High
Neurotransmitter 10 94.40 High High
Gabapentin 1 94.04 High High
Disease Link Frequency Relevance Heat
Obesity 13 99.68 Very High Very High Very High
Pancreatitis 6 98.92 Very High Very High Very High
Generalized Epilepsy 1 98.84 Very High Very High Very High
Epilepsy 11 97.66 Very High Very High Very High
Cancer 10 97.28 Very High Very High Very High
Necrosis 3 95.44 Very High Very High Very High
Breast Cancer 10 93.88 High High
Diabetes Mellitus 1 92.92 High High
Calcification 2 91.08 High High
Syndrome 3 86.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Accumulation of mitochondrial P450MT2, NH(2)-terminal truncated cytochrome P4501A1 in rat brain during chronic treatment with beta-naphthoflavone.
Positive_regulation (Accumulation) of P450MT2 in brain
1) Confidence 0.70 Published 2000 Journal J. Biol. Chem. Section Title Doc Link 10915793 Disease Relevance 0.08 Pain Relevance 0
The ED50 value for CYP1A1 induction (measured by ethoxyresorufin O-deethylase activity and radioimmunoassay (RIA) was estimated to be 0.8-1.0 nmol/kg, similar to what has been reported for TCDD.
Positive_regulation (induction) of CYP1A1
2) Confidence 0.68 Published 1991 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1949032 Disease Relevance 0 Pain Relevance 0.09
From this data, we conclude that a single dose of ketamine mildly inhibits the activity of CYP2D1 and CYP3A, and a single dose of urethane strongly inhibits CYP3A but increases CYP1A activity.
Positive_regulation (increases) of CYP1A associated with ketamine
3) Confidence 0.61 Published 1995 Journal Pharmacology Section Abstract Doc Link 7746831 Disease Relevance 0 Pain Relevance 0.23
In keeping with this finding, detailed social histories identified a higher exposure level in the patients to xenobiotics that are inducers of cytochrome P-450I and/or yield reactive metabolites upon processing thereby (score 7, 4-11 vs 3, 2-9, p = 0.002).
Positive_regulation (inducers) of cytochrome P-450I
4) Confidence 0.59 Published 1990 Journal Int J Clin Pharmacol Ther Toxicol Section Abstract Doc Link 2376424 Disease Relevance 0.33 Pain Relevance 0.23
Evidence for induction of cytochrome P-450I in patients with tropical chronic pancreatitis.
Positive_regulation (induction) of cytochrome P-450I associated with chronic pancreatitis
5) Confidence 0.59 Published 1990 Journal Int J Clin Pharmacol Ther Toxicol Section Title Doc Link 2376424 Disease Relevance 0.35 Pain Relevance 0.25
Methadone-HCl added to the drinking water of adult female Wistar rats for 4 weeks produced an increase in the aryl hydrocarbon hydroxylase activity of the hepatic microsomal fraction to 222% of control levels.
Positive_regulation (increase) of aryl hydrocarbon hydroxylase associated with methadone
6) Confidence 0.59 Published 1977 Journal Drug Metab. Dispos. Section Abstract Doc Link 15816 Disease Relevance 0 Pain Relevance 0.17
Induction of hepatic aryl hydrocarbon hydroxylase and epoxide hydrase in Wistar rats pretreated with oral methadone hydrochloride.
Positive_regulation (Induction) of aryl hydrocarbon hydroxylase associated with methadone
7) Confidence 0.59 Published 1977 Journal Drug Metab. Dispos. Section Title Doc Link 15816 Disease Relevance 0 Pain Relevance 0.37
Diether ether is known to be metabolized by cytochrome P450 IIE1 which is induced by fasting and by diethyl ether, and is possibly involved in the observed radical production, lipid peroxidation, and loss of cytochromes P-450.
Positive_regulation (induced) of cytochrome P450 IIE1
8) Confidence 0.55 Published 1991 Journal Xenobiotica Section Abstract Doc Link 2058176 Disease Relevance 0.07 Pain Relevance 0
In a second set of studies, the dose-response profiles for induction of cytochromes CYP1A1 and CYP1A2 by TBDD were characterized.
Positive_regulation (induction) of CYP1A1
9) Confidence 0.49 Published 1991 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1949032 Disease Relevance 0 Pain Relevance 0.09
Disposition of 2,3,7,8-tetrabromodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat: biliary excretion and induction of cytochromes CYP1A1 and CYP1A2.
Positive_regulation (induction) of CYP1A1
10) Confidence 0.46 Published 1991 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 1949032 Disease Relevance 0 Pain Relevance 0.12
The PB-induced up-regulation of CYP2B, CYP2E1 and CYP1A1 isozymes was markedly higher in CD than in NF rats.
Positive_regulation (up-regulation) of CYP1A1
11) Confidence 0.45 Published 2009 Journal J Appl Toxicol Section Abstract Doc Link 18798224 Disease Relevance 0 Pain Relevance 0.62
Accumulation of mitochondrial P450MT2, NH(2)-terminal truncated cytochrome P4501A1 in rat brain during chronic treatment with beta-naphthoflavone.
Positive_regulation (Accumulation) of cytochrome P4501A1 in brain
12) Confidence 0.41 Published 2000 Journal J. Biol. Chem. Section Title Doc Link 10915793 Disease Relevance 0.08 Pain Relevance 0.05
Cytochrome P450 I (EROD activity) was decreased to 35-44% of control values by the ether anaesthesia and was restored to 80% of normal levels 2 h later. 5.
Positive_regulation (restored) of Cytochrome P450 I
13) Confidence 0.37 Published 1991 Journal Xenobiotica Section Abstract Doc Link 2058176 Disease Relevance 0.07 Pain Relevance 0
FFx increased the mRNA level of CYP1A1; an increase that was not prevented by GdCl3.
Positive_regulation (increased) of CYP1A1
14) Confidence 0.35 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 14723344 Disease Relevance 0.49 Pain Relevance 0.08
The most frequent genotypes in the sample were CYP1A1 wt/wt, with GSTM1 null deletion and at least one functional allele of GSTT1, and CYP1A1 wt/wt, with at least one functional allele of GSTM1 and GSTT1 (33% and 31%, respectively).
Positive_regulation (allele) of CYP1A1
15) Confidence 0.21 Published 2001 Journal Fertil. Steril. Section Body Doc Link 11730751 Disease Relevance 0.06 Pain Relevance 0
In addition, cytochrome P450 IA1 was strongly induced by methylcholanthrene in adult rat hepatocyte spheroids, and the induction remained relatively constant up to 22 days of culture.
Positive_regulation (induced) of cytochrome P450 IA1 in hepatocyte
16) Confidence 0.20 Published 1992 Journal Exp. Cell Res. Section Abstract Doc Link 1572400 Disease Relevance 0 Pain Relevance 0.14
As such, CYP1A1, GST and AhRR mRNA would be induced if functional AhR is expressed in N2a-R?.
Positive_regulation (induced) of CYP1A1
17) Confidence 0.18 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0 Pain Relevance 0
CYP1A1, a typical XRE-regulated gene, mRNA was induced without the application of ligand to the culture medium.
Positive_regulation (induced) of CYP1A1
18) Confidence 0.17 Published 2006 Journal Environ Health Section Abstract Doc Link PMC1570454 Disease Relevance 0.20 Pain Relevance 0.08
CYP1A was undetectable in RMTCs while CYP1A induction by beta-naphthoflavone in MCF-7 cells was significantly inhibited by SA in a concentration-dependent manner.
Positive_regulation (induction) of CYP1A in MCF-7
19) Confidence 0.14 Published 2006 Journal Int. J. Oncol. Section Abstract Doc Link 16596229 Disease Relevance 0.84 Pain Relevance 0.27
CYP1A was undetectable in RMTCs while CYP1A induction by beta-naphthoflavone in MCF-7 cells was significantly inhibited by SA in a concentration-dependent manner.
Positive_regulation (induction) of CYP1A in MCF-7
20) Confidence 0.14 Published 2006 Journal Int. J. Oncol. Section Abstract Doc Link 16596229 Disease Relevance 0.85 Pain Relevance 0.27

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