INT186022

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Context Info
Confidence 0.28
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 2.09
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Fig4) Golgi apparatus (Fig4) endoplasmic reticulum (Fig4)
Anatomy Link Frequency
hepatocytes 4
neuron 2
satellite cells 2
Fig4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 98 98.12 Very High Very High Very High
Bile 183 97.44 Very High Very High Very High
antagonist 80 95.92 Very High Very High Very High
agonist 31 87.88 High High
chemokine 104 83.36 Quite High
Peripheral nerve injury 6 71.28 Quite High
imagery 12 60.80 Quite High
noradrenaline 10 50.16 Quite High
Neuropathic pain 24 47.00 Quite Low
qutenza 14 31.60 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 98 98.12 Very High Very High Very High
Fistula 57 97.76 Very High Very High Very High
Injury 66 93.84 High High
Neuropathic Pain 32 91.52 High High
Nervous System Injury 16 71.28 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 42 50.00 Quite Low
Toxicity 3 24.64 Low Low
Nociception 14 13.64 Low Low
Neuropathy 26 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M) was not blocked by gene transcription (Fig. 3A) or protein synthesis (Fig. 3B) inhibitor.
Negative_regulation (blocked) of Transcription (transcription) of Fig
1) Confidence 0.28 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1201169 Disease Relevance 0 Pain Relevance 0.05
M) was not blocked by gene transcription (Fig. 3A) or protein synthesis (Fig. 3B) inhibitor.
Negative_regulation (inhibitor) of Transcription (transcription) of Fig
2) Confidence 0.28 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1201169 Disease Relevance 0 Pain Relevance 0.07
50%, 30 min) downregulated mRNA levels of PEPCK and G-6-Pase (Fig. 2).
Negative_regulation (downregulated) of Transcription (levels) of Fig
3) Confidence 0.14 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.24 Pain Relevance 0.27
The addition of TCA alone to primary rat hepatocytes in culture rapidly (1–2 h) downregulated both PEPCK (Fig. 3A) and G-6-Pase mRNA levels (Fig. 3B).
Negative_regulation (downregulated) of Transcription (levels) of Fig in hepatocytes
4) Confidence 0.14 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.21 Pain Relevance 0.21
The addition of TCA alone to primary rat hepatocytes in culture rapidly (1–2 h) downregulated both PEPCK (Fig. 3A) and G-6-Pase mRNA levels (Fig. 3B).
Negative_regulation (downregulated) of Transcription (levels) of Fig in hepatocytes
5) Confidence 0.14 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.21 Pain Relevance 0.21
Importantly, blocking FAK function failed to inhibit EGF-stimulated Grb7 and KOR mRNA export (Fig. 5 A, right), suggesting the specificity of FAK in phosphorylating cytoplasmic Grb7.
Negative_regulation (inhibit) of Transcription (export) of Fig
6) Confidence 0.11 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0
Notably satellite cells under these conditions lacked both CXCR4 mRNA transcripts and protein expression (Fig. 4E, F).
Negative_regulation (lacked) of Transcription (expression) of Fig in satellite cells
7) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.29 Pain Relevance 0.18
Lumbar DRG in the naïve (data not shown), vehicle treated and gp120/hCD4 only treated rats were largely devoid of the SDF1 mRNA transcripts with the exception of the occasional neuron (Fig. 6D, E).
Negative_regulation (devoid) of Transcription (transcripts) of Fig in neuron associated with dorsal root ganglion
8) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 1.14 Pain Relevance 0.51

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