INT186057

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Context Info
Confidence 0.31
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.92
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCND1) nucleoplasm (CCND1) nucleus (CCND1)
intracellular (CCND1) enzyme binding (CCND1) cell division (CCND1)
Anatomy Link Frequency
lymphocytes 1
CCND1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 13 85.32 High High
headache 2 76.88 Quite High
Inflammation 34 48.40 Quite Low
antagonist 5 17.40 Low Low
COX-2 inhibitor 52 5.00 Very Low Very Low Very Low
cINOD 18 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 225 99.32 Very High Very High Very High
Hyperplasia 2 98.08 Very High Very High Very High
Stress 31 96.56 Very High Very High Very High
Metastasis 50 94.16 High High
Recurrence 15 93.36 High High
Lymphatic System Cancer 52 91.08 High High
Cancer 395 88.28 High High
Apoptosis 178 87.28 High High
Convulsion 2 77.28 Quite High
Headache 2 76.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, specific cyclin D1 isoforms are associated with discrete forms of breast cancer and high cyclin D1b protein levels hold prognostic potential.
cyclin D1 Binding (associated) of associated with breast cancer
1) Confidence 0.31 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.96 Pain Relevance 0
In addition, CCND1 also interacted with marine n-3 and n-6 fatty acids to influence breast cancer risk, with the protection being restricted to women with a high intake level of n-6 fatty acids, or a low intake level of marine n-3 fatty acids [139].
CCND1 Binding (interacted) of associated with breast cancer
2) Confidence 0.27 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1851400 Disease Relevance 0.97 Pain Relevance 0
Additionally, we could not find an association with cyclin D1 [Table 3] and Ki-67.
cyclin D1 Neg (not) Binding (association) of
3) Confidence 0.23 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 0.83 Pain Relevance 0
In the present study, we did not find any significant association between p27, cyclin D1 and proliferative activity.
cyclin D1 Neg (not) Binding (association) of
4) Confidence 0.22 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 0.50 Pain Relevance 0
One key nuclear function of EGFR is phosphorylation and activation of DNA-dependent protein kinase (DNA-PK), an enzyme that is involved in repair of breaks in double-stranded DNA caused by radiation and chemotherapy.18,19 EGFR localizing to the nuclear compartment can also enter transcriptional complexes and bind to the promoter region of cyclin D1 to promote cell cycle progression and increase cellular proliferation.20 EGFR inhibition delays the repair of chemotherapy-induced DNA damage via modulation of DNA repair genes such as XRCC1 and ERCC1, which could explain some of the increased activity of cisplatin when combined with EGFR inhibitors such as cetuximab.21–23
cyclin D1 Binding (bind) of associated with hyperplasia
5) Confidence 0.12 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2921255 Disease Relevance 0.28 Pain Relevance 0
If phosphorylation occurs on T157 and T198 by PI3K (phosphoinositide 3-kinase), it triggers cell cycle transition by stabilizing the cyclin D1/cdk4 complex [55].
cyclin D1 Binding (complex) of
6) Confidence 0.10 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.83 Pain Relevance 0
The lymphocytes express B-cell markers (CD19, CD20, and CD79a) and are negative for CD3, CD5, CD10, CD23, and cyclin D1.
cyclin D1 Binding (negative) of in lymphocytes
7) Confidence 0.09 Published 2008 Journal J Hematop Section Body Doc Link PMC2713483 Disease Relevance 1.49 Pain Relevance 0.26
To examine the randomness of the transposition event the transposon with its flanking DNA was rescued from 33 colonies by digesting the DNA with Bcl1, self-ligating the fragments, and introducing them into pir+E. coli.
Bcl1 Binding (ligating) of
8) Confidence 0.05 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1557513 Disease Relevance 0.06 Pain Relevance 0

General Comments

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