INT186063

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Context Info
Confidence 0.28
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 29
Total Number 29
Disease Relevance 11.77
Pain Relevance 5.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (SOAT1) transferase activity, transferring acyl groups (SOAT1)
Anatomy Link Frequency
blood 4
chondrocytes 2
livers 2
monocyte 1
nucleus 1
SOAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 512 100.00 Very High Very High Very High
Kinase C 11 99.56 Very High Very High Very High
Potency 236 98.80 Very High Very High Very High
Arthritis 442 97.70 Very High Very High Very High
agonist 132 95.92 Very High Very High Very High
Osteoarthritis 162 94.08 High High
Inflammatory response 15 94.00 High High
Inflammatory mediators 19 93.72 High High
alcohol 14 91.36 High High
Inflammation 415 88.64 High High
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 15 99.28 Very High Very High Very High
Obesity 323 99.12 Very High Very High Very High
Cirrhosis 114 98.76 Very High Very High Very High
Apoptosis 125 97.96 Very High Very High Very High
Arthritis 481 97.70 Very High Very High Very High
Small Cell Lung Carcinoma 1 97.20 Very High Very High Very High
Necrosis 23 96.48 Very High Very High Very High
Stress 86 96.24 Very High Very High Very High
Cancer 58 96.12 Very High Very High Very High
Malignant Neoplastic Disease 8 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
STAT proteins are then phosphorylated and translocated to the nucleus, which initiates transcription of growth hormone target proteins (Argetsinger et al 1993).
Phosphorylation (phosphorylated) of STAT in nucleus
1) Confidence 0.28 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 0.07 Pain Relevance 0.04
By contrast, the phosphorylation of STAT 5A and 5B in leptin-stimulated chondrocytes remained unchanged compared with untreated cells (data not shown).
Phosphorylation (phosphorylation) of STAT in chondrocytes
2) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.12 Pain Relevance 0.10
In the current study, the elevated concentration of leptin actually induced the phosphorylation of STAT 1?
Phosphorylation (phosphorylation) of STAT
3) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.67 Pain Relevance 0.04
The responsiveness to the cytokines was defined by measurable phosphorylation of STAT and ERK.
Phosphorylation (phosphorylation) of STAT associated with cytokine
4) Confidence 0.24 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.37 Pain Relevance 0.24
In other studies the levels of STAT phosphorylation indicated phosphorylated STAT3 protein in HCV affected cirrhotic livers compared to primary biliary cirrhotic samples and healthy tissue [26].
Phosphorylation (phosphorylation) of STAT in livers associated with cirrhosis and hepatitis c virus infection
5) Confidence 0.21 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.39 Pain Relevance 0.05
In other studies the levels of STAT phosphorylation indicated phosphorylated STAT3 protein in HCV affected cirrhotic livers compared to primary biliary cirrhotic samples and healthy tissue [26].
Phosphorylation (phosphorylated) of STAT in livers associated with cirrhosis and hepatitis c virus infection
6) Confidence 0.21 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.40 Pain Relevance 0.05
As STAT 1 has been found to act as a negative transcriptional regulator [23,24], leptin-induced STAT 1 phosphorylation in chondrocytes from obese patients may interfere with the transcriptional machinery and may lead to the loss of cell sensitivity to leptin.
Phosphorylation (phosphorylation) of STAT in chondrocytes associated with obesity
7) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.72 Pain Relevance 0.05
Since JAKs directly phosphorylate STAT proteins in response to specific cytokine stimulation, measuring the extent of STAT phosphorylation in cells is an indirect measurement of JAK inhibition.
Phosphorylation (phosphorylate) of STAT associated with cytokine
8) Confidence 0.09 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0 Pain Relevance 0.30
The potency and selectivity of CP-690,550 were therefore assessed in vitro in whole blood using intracellular flow cytometry to measure STAT phosphorylation.
Phosphorylation (phosphorylation) of STAT in blood associated with potency
9) Confidence 0.09 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0 Pain Relevance 0.34
Since JAKs directly phosphorylate STAT proteins in response to specific cytokine stimulation, measuring the extent of STAT phosphorylation in cells is an indirect measurement of JAK inhibition.
Phosphorylation (phosphorylation) of STAT associated with cytokine
10) Confidence 0.09 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0 Pain Relevance 0.30
Although we did not directly evaluate inhibition of JAK2 or in vitro granulopoiesis in the rat, inhibition of arthritis, cytokines and neutrophilia in the AIA model were observed at plasma exposures that were well below the human JAK2 IC50 and effects on GM-CSF stimulated STAT phosphorylation in the rat whole blood assay.
Phosphorylation (phosphorylation) of STAT in blood associated with cytokine and arthritis
11) Confidence 0.09 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0.64 Pain Relevance 0.38
Percent of control STAT phosphorylation was determined at each concentration of CP-690,550 by comparison of Ax647 MCF with those from unstimulated and cytokine stimulated controls.
Phosphorylation (phosphorylation) of STAT associated with cytokine
12) Confidence 0.09 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0 Pain Relevance 0.08
After ligand binding, STAT proteins are recruited to the cytokine receptors and phosphorylated on tyrosine residues by Janus tyrosine kinases (Jaks) [76].
Phosphorylation (phosphorylated) of STAT associated with cytokine
13) Confidence 0.09 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.09 Pain Relevance 0.10
[33,37] and dependent upon the induction of the signal transducer and activator of transcription (STAT) STAT1 phosphorylation [38].
Phosphorylation (phosphorylation) of STAT
14) Confidence 0.09 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.61 Pain Relevance 0
Inhibition of JAK-dependent STAT phosphorylation in whole blood was also examined as a measure of JAK potency and selectivity.
Phosphorylation (phosphorylation) of STAT in blood associated with potency
15) Confidence 0.07 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0.18 Pain Relevance 0.36
The in vitro potency and selectivity of CP-690,550 were determined using recombinant human kinases and whole blood cytokine induced STAT phosphorylation assays.
Phosphorylation (phosphorylation) of STAT in blood associated with cytokine and potency
16) Confidence 0.07 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0.96 Pain Relevance 0.57
Normal human, mouse or rat whole blood pre-treated with CP-690,550 was stimulated with cytokines, and STAT phosphorylation downstream of receptor-associated JAK activation was monitored in monocyte and T cell populations as summarized in Table 1.
Phosphorylation (phosphorylation) of STAT in T cell associated with cytokine
17) Confidence 0.07 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0 Pain Relevance 0.35
Interestingly, in addition to tyrosine phosphorylation, STAT proteins in vertebrates can also be phosphorylated at a serine residue [77].
Phosphorylation (phosphorylation) of STAT
18) Confidence 0.07 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.08 Pain Relevance 0.09
Interestingly, in addition to tyrosine phosphorylation, STAT proteins in vertebrates can also be phosphorylated at a serine residue [77].
Phosphorylation (phosphorylated) of STAT
19) Confidence 0.07 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.08 Pain Relevance 0.09
the phosphorylation of signal transducers and activators of transcription

(STAT) 1 and 3 as well as Janus kinase 1 (JAK1) and JAK2 in activated

Phosphorylation (phosphorylation) of STAT
20) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2367430 Disease Relevance 0.29 Pain Relevance 0.32

General Comments

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