INT186065

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Context Info
Confidence 0.25
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.95
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (STAT1) nucleoplasm (STAT1) nucleolus (STAT1)
nucleus (STAT1) enzyme binding (STAT1) cytoplasm (STAT1)
Anatomy Link Frequency
epithelial cells 2
STAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 96 84.84 Quite High
Inflammation 100 39.84 Quite Low
antagonist 34 5.00 Very Low Very Low Very Low
chemokine 25 5.00 Very Low Very Low Very Low
agonist 21 5.00 Very Low Very Low Very Low
Chronic pancreatitis 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 315 95.72 Very High Very High Very High
Cancer 43 91.72 High High
Hypoxia 2 89.44 High High
Pancreatic Cancer 8 89.08 High High
Hepatitis C Virus Infection 1 87.28 High High
Targeted Disruption 20 86.48 High High
Dengue 34 74.56 Quite High
Renal Cancer 1 73.12 Quite High
Viral Meningitis 3 72.24 Quite High
Infection 59 71.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Epigenetic level control, such as methylation, may represent an additional mechanism since a strict correlation exists between demethylation and enhancements in STAT-1 phosphorylation followed by an increase in ISG expression [39].
Positive_regulation (enhancements) of Phosphorylation (phosphorylation) of STAT-1
1) Confidence 0.25 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.85 Pain Relevance 0
In vitro this SNPs enhances the transcription of SOCS1 in human lung epithelial cells, but reduces phosphorylation of STAT1 stimulated with IFN-?
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of STAT1 in epithelial cells
2) Confidence 0.20 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.48 Pain Relevance 0.10
[33,37] and dependent upon the induction of the signal transducer and activator of transcription (STAT) STAT1 phosphorylation [38].
Positive_regulation (induction) of Phosphorylation (phosphorylation) of STAT1
3) Confidence 0.17 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.62 Pain Relevance 0

General Comments

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