INT186116

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2010
Negated 6
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 5.85
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK1) mitochondrion (MAPK1) Golgi apparatus (MAPK1)
DNA binding (MAPK1) protein complex (MAPK1) response to stress (MAPK1)
Anatomy Link Frequency
colon 2
MAPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 300 97.24 Very High Very High Very High
antagonist 30 93.60 High High
agonist 12 92.44 High High
Cannabinoid receptor 96 92.12 High High
Inflammation 183 89.56 High High
Osteoarthritis 267 87.84 High High
rheumatoid arthritis 297 87.56 High High
imagery 23 82.76 Quite High
Endocannabinoid 129 62.64 Quite High
Cannabinoid 15 52.08 Quite High
Disease Link Frequency Relevance Heat
Colon Cancer 50 99.40 Very High Very High Very High
Targeted Disruption 19 97.72 Very High Very High Very High
Stress 408 97.52 Very High Very High Very High
INFLAMMATION 179 89.56 High High
Frailty 270 87.84 High High
Rheumatoid Arthritis 297 87.56 High High
Disease 813 84.16 Quite High
Death 24 82.36 Quite High
Apoptosis 166 81.92 Quite High
Prostate Cancer 27 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Total cellular levels of ERK, JNK, and p38 proteins did not change significantly over the time courses of up to 1 hour incubation with BK or H2O2.


Neg (not) Regulation (change) of Gene_expression (levels) of ERK associated with bradykinin
1) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0 Pain Relevance 0.09
Cell lysates collected in 1% SDS were immunoblotted for expression and activation of ERK, JNK and p38 and normalized to the loading control protein tubulin.
Regulation (immunoblotted) of Gene_expression (expression) of ERK
2) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.36 Pain Relevance 0.25
Total cellular levels of ERK, JNK, and p38 proteins did not change significantly over the time courses of up to 1 hour incubation with BK or H2O2.


Neg (not) Regulation (change) of Gene_expression (levels) of p38 associated with bradykinin
3) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0 Pain Relevance 0.09
Cell lysates collected in 1% SDS were immunoblotted for expression and activation of ERK, JNK and p38 and normalized to the loading control protein tubulin.
Regulation (immunoblotted) of Gene_expression (expression) of p38
4) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.42 Pain Relevance 0.25
Levels of total ERK1, ERK2, and p38 were unaffected by HU210 (data not shown).
Neg (unaffected) Regulation (unaffected) of Gene_expression (Levels) of ERK2
5) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453762 Disease Relevance 0.86 Pain Relevance 0.58
Levels of total ERK1, ERK2, and p38 were unaffected by HU210 (data not shown).
Neg (unaffected) Regulation (unaffected) of Gene_expression (Levels) of p38
6) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453762 Disease Relevance 0.86 Pain Relevance 0.58
Levels of total ERK1 and ERK2 were unaffected by the drug treatments (Figure 7a).
Neg (unaffected) Regulation (unaffected) of Gene_expression (Levels) of ERK2
7) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453762 Disease Relevance 0.26 Pain Relevance 0.44
There was no effect of drug or EGF treatment on total ERK1/2 expression.
Neg (no) Regulation (effect) of Gene_expression (expression) of ERK1/2
8) Confidence 0.20 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.35 Pain Relevance 0
In order to verify that EGFR signaling was intact in our cells, the effects of EGF treatment on the expression and activation of EGFR and ERK1/2 in HT29 human colon cancer cells was examined.
Spec (examined) Regulation (effects) of Gene_expression (expression) of ERK1/2 in colon associated with colon cancer
9) Confidence 0.12 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.26 Pain Relevance 0.04
We then calculated the effect of these perturbation on cyclin D and PSA expression levels along with ERK and AR activation levels.
Regulation (effect) of Gene_expression (expression) of ERK
10) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.49 Pain Relevance 0

General Comments

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