INT186118

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Context Info
Confidence 0.68
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.66
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (EGFR) cell morphogenesis (EGFR) Golgi apparatus (EGFR)
endoplasmic reticulum (EGFR) intracellular (EGFR) enzyme binding (EGFR)
EGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 56 94.40 High High
adenocard 2 92.40 High High
aspirin 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Immobilon 4 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 70 88.08 High High
Colon Cancer 50 62.72 Quite High
Cancer 8 47.24 Quite Low
Disease 2 18.28 Low Low
Death 18 5.00 Very Low Very Low Very Low
Familial Adenomatous Polyposis 10 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Adenoma 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have not systematically examined the mechanism by which sulindac metabolites downregulate EGFR but the relatively short time course (as early as 1 hour) suggests that the effect is more likely due to increased degradation of EGFR rather than inhibition of new protein synthesis.
Positive_regulation (increased) of Protein_catabolism (degradation) of EGFR
1) Confidence 0.68 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.30 Pain Relevance 0.30
We have not systematically examined the mechanism by which sulindac metabolites downregulate EGFR but the relatively short time course (as early as 1 hour) suggests that the effect is more likely due to increased degradation of EGFR rather than inhibition of new protein synthesis.
Positive_regulation (increased) of Protein_catabolism (degradation) of EGFR
2) Confidence 0.43 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.35 Pain Relevance 0.38

General Comments

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