INT186119

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.98
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.68
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (EGFR) cell morphogenesis (EGFR) Golgi apparatus (EGFR)
endoplasmic reticulum (EGFR) intracellular (EGFR) enzyme binding (EGFR)
EGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 56 94.40 High High
adenocard 2 92.40 High High
Inflammation 9 83.16 Quite High
Paracetamol 2 47.24 Quite Low
palliative 1 24.32 Low Low
aspirin 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Immobilon 4 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 11 99.84 Very High Very High Very High
Lung Cancer 48 99.44 Very High Very High Very High
Cancer 100 97.84 Very High Very High Very High
Apoptosis 89 88.08 High High
Toxicity 35 85.92 High High
INFLAMMATION 14 83.16 Quite High
Advanced Or Metastatic Breast Cancer 62 82.72 Quite High
Nicotine Addiction 18 80.00 Quite High
Breast Cancer 46 72.60 Quite High
Volume Depletion And Dehydration 2 69.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have not systematically examined the mechanism by which sulindac metabolites downregulate EGFR but the relatively short time course (as early as 1 hour) suggests that the effect is more likely due to increased degradation of EGFR rather than inhibition of new protein synthesis.
Protein_catabolism (degradation) of EGFR
1) Confidence 0.98 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.30 Pain Relevance 0.30
Mutation analysis of EGFR in malignant mesothelioma
Protein_catabolism (analysis) of EGFR associated with malignant neoplastic disease and lung cancer
2) Confidence 0.89 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2970593 Disease Relevance 1.00 Pain Relevance 0
We have not systematically examined the mechanism by which sulindac metabolites downregulate EGFR but the relatively short time course (as early as 1 hour) suggests that the effect is more likely due to increased degradation of EGFR rather than inhibition of new protein synthesis.
Protein_catabolism (degradation) of EGFR
3) Confidence 0.76 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.35 Pain Relevance 0.38
Interestingly, this property determines canertinib’s ability to induce ubiquitylation and degradation of both ErbB1 and ErbB2 [75], a property not shared by reversible TKIs.
Protein_catabolism (degradation) of ErbB1
4) Confidence 0.51 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2972555 Disease Relevance 0.91 Pain Relevance 0
The Rho-family small G-protein cell division cycle 42 homolog (Saccharomyces cerevisiae) (CDC42), controls progression through the cell cycle and also helps regulate degradation of the central carcinogenesis mediator, the epidermal growth factor receptor (EGFR) (Wu WJ et al. 2003).
Protein_catabolism (degradation) of epidermal growth factor receptor
5) Confidence 0.48 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2290973 Disease Relevance 0.55 Pain Relevance 0.04
The Rho-family small G-protein cell division cycle 42 homolog (Saccharomyces cerevisiae) (CDC42), controls progression through the cell cycle and also helps regulate degradation of the central carcinogenesis mediator, the epidermal growth factor receptor (EGFR) (Wu WJ et al. 2003).
Protein_catabolism (degradation) of EGFR
6) Confidence 0.48 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2290973 Disease Relevance 0.56 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox