INT186121

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 2.77
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Agxt) peroxisome (Agxt)
Anatomy Link Frequency
neurons 1
Agxt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 11 93.92 High High
GABAergic 117 87.28 High High
Pyramidal cell 5 80.52 Quite High
tetrodotoxin 29 56.20 Quite High
imagery 19 22.08 Low Low
agonist 12 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
Action potential 9 5.00 Very Low Very Low Very Low
interneuron 6 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 13 99.96 Very High Very High Very High
Hypersensitivity 116 99.72 Very High Very High Very High
Bites And Stings 50 90.56 High High
Insect Bites And Stings 14 75.00 Quite High
Glioma 37 57.04 Quite High
Cancer 31 46.56 Quite Low
Anaplastic Astrocytoma 2 31.16 Quite Low
Primitive Neuroectodermal Tumors 1 30.44 Quite Low
Ganglion Cysts 6 22.08 Low Low
Infection 8 16.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The repair of the chloroethyl adducts is conducted by O6-alkylguanine-DNA alkyltransferase (AGT or MGMT).
Gene_expression (alkyltransferase) of AGT
1) Confidence 0.65 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376068 Disease Relevance 0.06 Pain Relevance 0
-BT labeling and SPT trajectories on labeled cells confirmed random QD labeling across the entire population of ?
Gene_expression (trajectories) of SPT
2) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2901346 Disease Relevance 0 Pain Relevance 0
Long-term overexpression of PICK1 (or the inactive PDZ-domain mutant) was attempted but resulted in toxicity; SPT analysis after 24 h revealed no significant effect of PICK1 on ?
Gene_expression (analysis) of SPT associated with toxicity
3) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2901346 Disease Relevance 0.10 Pain Relevance 0.11
Therefore, several additional aspects of our study differ from previous SPT investigations of ligand-gated ion channels, which deserve consideration:
Spec (investigations) Gene_expression (previous) of SPT
4) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2901346 Disease Relevance 0 Pain Relevance 0.24
In accordance with these results, our SPT studies revealed that both treatments significantly reduced the synaptic dwell time of Eag1 (0.52±0.04 s, n?
Gene_expression (studies) of SPT
5) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810327 Disease Relevance 0 Pain Relevance 0
In conclusion, our data demonstrate that mAb62 is able to detect endogenous Eag1 in rat hippocampal neurons and, therefore, serves as a tool for performing SPT studies.


Gene_expression (studies) of SPT in neurons
6) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810327 Disease Relevance 0 Pain Relevance 0.04
The SPT became negative in 68% of the wasp allergic patients after five years of adequate IT.
Neg (negative) Gene_expression (negative) of SPT associated with hypersensitivity
7) Confidence 0.05 Published 2005 Journal Clin Mol Allergy Section Abstract Doc Link PMC1208928 Disease Relevance 1.05 Pain Relevance 0
For bee allergic patients the SPT became negative in 74.3% of the adequately treated ones.
Neg (negative) Gene_expression (negative) of SPT associated with hypersensitivity
8) Confidence 0.05 Published 2005 Journal Clin Mol Allergy Section Body Doc Link PMC1208928 Disease Relevance 1.55 Pain Relevance 0

General Comments

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