INT186125

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.12
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.04
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD2, CD58) extracellular region (CD2) cell adhesion (CD58)
Anatomy Link Frequency
T cell 4
hinge 2
CD2 (Homo sapiens)
CD58 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 100 99.52 Very High Very High Very High
Arthritis 223 98.88 Very High Very High Very High
rheumatoid arthritis 69 97.20 Very High Very High Very High
psoriasis 74 92.24 High High
methotrexate 7 89.60 High High
backache 2 67.84 Quite High
Adalimumab 12 67.36 Quite High
Infliximab 36 43.92 Quite Low
cytokine 42 17.80 Low Low
abatacept 3 14.88 Low Low
Disease Link Frequency Relevance Heat
Disease 54 99.70 Very High Very High Very High
INFLAMMATION 95 99.52 Very High Very High Very High
Seronegative Spondarthritis 184 98.88 Very High Very High Very High
Rheumatoid Arthritis 69 97.20 Very High Very High Very High
Skin Diseases 6 94.92 High High
Psoriasis 94 92.24 High High
Arthritis 47 89.08 High High
Autoimmune Disease 23 84.36 Quite High
Infection 13 79.28 Quite High
Apoptosis 2 78.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The LFA-3 portion of alefacept binds to CD2 receptors on T cells to block the natural interaction between LFA-3 on antigen-presenting cells and CD2 on T cells.
Negative_regulation (block) of CD2 Binding (interaction) of LFA-3 in T cells
1) Confidence 0.12 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1208938 Disease Relevance 0.97 Pain Relevance 0.38
This study supports the notion that T cell activation plays an important role in chronic inflammatory diseases and effective blockade of the LFA-3/CD2 interaction may be useful for treating PsA.
Negative_regulation (blockade) of CD2 Binding (interaction) of LFA-3 in T cell associated with inflammation, disease and arthritis
2) Confidence 0.12 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1208938 Disease Relevance 1.23 Pain Relevance 0.44
Interaction of CD2 with its ligand, CD58 has been blocked by application of a soluble fully human recombinant fusion protein comprising the first extracellular domain of CD58 and the hinge, CH2 and CH3 sequences of human IgG1 (LFA-3-IgG1; alefacept).
Negative_regulation (blocked) of CD2 Binding (Interaction) of CD58 in hinge
3) Confidence 0.10 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.84 Pain Relevance 0.24

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox