INT186127

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Context Info
Confidence 0.19
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.74
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CTLA4, CD28) cytosol (CD28) Golgi apparatus (CTLA4)
CTLA4 (Homo sapiens)
CD28 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 105 87.80 High High
psoriasis 35 85.44 High High
abatacept 1 77.28 Quite High
rheumatoid arthritis 8 72.40 Quite High
Inflammation 19 60.92 Quite High
cytokine 9 47.36 Quite Low
antagonist 1 7.12 Low Low
Infliximab 18 5.00 Very Low Very Low Very Low
Etanercept 14 5.00 Very Low Very Low Very Low
Adalimumab 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Seronegative Spondarthritis 92 87.80 High High
Psoriasis 45 85.44 High High
Disease 15 73.08 Quite High
Rheumatoid Arthritis 8 72.40 Quite High
INFLAMMATION 18 60.92 Quite High
Arthropathy 8 39.00 Quite Low
Autoimmune Disease 3 25.44 Quite Low
Arthritis 17 5.00 Very Low Very Low Very Low
Infection 5 5.00 Very Low Very Low Very Low
Disease Progression 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CTLA-4, a natural inhibitor of CD28, binds to CD80/86 molecules with high affinity and competes with CD28.
CTLA-4 Negative_regulation (inhibitor) of CD28
1) Confidence 0.19 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1208938 Disease Relevance 0.74 Pain Relevance 0.32

General Comments

This test has worked.

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