INT186128

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Context Info
Confidence 0.10
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 7.59
Pain Relevance 2.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD2, CD58) extracellular region (CD2) cell adhesion (CD58)
Anatomy Link Frequency
T cells 7
hinge 1
CD2 (Homo sapiens)
CD58 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 108 99.76 Very High Very High Very High
Arthritis 652 99.48 Very High Very High Very High
Inflammation 192 99.20 Very High Very High Very High
psoriasis 286 95.92 Very High Very High Very High
methotrexate 24 89.60 High High
Adalimumab 38 69.92 Quite High
backache 6 67.84 Quite High
cytokine 87 65.92 Quite High
Infliximab 138 46.48 Quite Low
Etanercept 121 44.64 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 108 99.76 Very High Very High Very High
Seronegative Spondarthritis 560 99.48 Very High Very High Very High
Disease 127 99.38 Very High Very High Very High
INFLAMMATION 184 99.20 Very High Very High Very High
Psoriasis 365 95.92 Very High Very High Very High
Skin Diseases 20 94.28 High High
Arthritis 115 88.44 High High
Autoimmune Disease 35 84.36 Quite High
Apoptosis 7 82.88 Quite High
Infection 44 81.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blockade of the LFA-3/CD2 interaction, a key co-stimulatory pathway, can inhibit T-cell activation.
CD2 Binding (interaction) of LFA-3 in T-cell
1) Confidence 0.10 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1208938 Disease Relevance 0.94 Pain Relevance 0.34
The LFA-3 portion of alefacept binds to CD2 receptors on T cells to block the natural interaction between LFA-3 on antigen-presenting cells and CD2 on T cells.
CD2 Binding (binds) of LFA-3 in T cells
2) Confidence 0.10 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1208938 Disease Relevance 0.97 Pain Relevance 0.38
This study supports the notion that T cell activation plays an important role in chronic inflammatory diseases and effective blockade of the LFA-3/CD2 interaction may be useful for treating PsA.
CD2 Binding (interaction) of LFA-3 in T cell associated with inflammation, disease and arthritis
3) Confidence 0.10 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1208938 Disease Relevance 1.22 Pain Relevance 0.44
Blockade of the LFA-3/CD2 interaction, a key co-stimulatory pathway, can inhibit T-cell activation.
CD2 Binding (interaction) of LFA-3 in T-cell
4) Confidence 0.10 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1208938 Disease Relevance 0.94 Pain Relevance 0.34
The LFA-3 portion of alefacept binds to CD2 receptors on T cells to block the natural interaction between LFA-3 on antigen-presenting cells and CD2 on T cells.
CD2 Binding (interaction) of LFA-3 in T cells
5) Confidence 0.10 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1208938 Disease Relevance 0.96 Pain Relevance 0.37
This study supports the notion that T cell activation plays an important role in chronic inflammatory diseases and effective blockade of the LFA-3/CD2 interaction may be useful for treating PsA.
CD2 Binding (interaction) of LFA-3 in T cell associated with inflammation, disease and arthritis
6) Confidence 0.10 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1208938 Disease Relevance 1.22 Pain Relevance 0.44
Interaction of CD2 with its ligand, CD58 has been blocked by application of a soluble fully human recombinant fusion protein comprising the first extracellular domain of CD58 and the hinge, CH2 and CH3 sequences of human IgG1 (LFA-3-IgG1; alefacept).
CD2 Binding (Interaction) of CD58 in hinge
7) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.83 Pain Relevance 0.23
Another molecular interaction implicated in the functional activation of T cells is the binding of the costimulatory receptor CD2 on T cell surface, to its ligand LFA-3 on antigen-presenting cells.
CD2 Binding (binding) of LFA-3 in T cells
8) Confidence 0.05 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727880 Disease Relevance 0.49 Pain Relevance 0.21

General Comments

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