INT186134

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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 4.71
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

IGHA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Adalimumab 430 100.00 Very High Very High Very High
rheumatoid arthritis 57 97.76 Very High Very High Very High
Inflammation 65 94.84 High High
Arthritis 122 94.64 High High
Etanercept 55 91.88 High High
psoriasis 107 86.00 High High
cytokine 26 80.56 Quite High
spinal inflammation 5 76.32 Quite High
methotrexate 24 75.32 Quite High
Infliximab 178 70.12 Quite High
Disease Link Frequency Relevance Heat
Toxicity 9 99.78 Very High Very High Very High
Pancreatitis 66 98.58 Very High Very High Very High
Rheumatoid Arthritis 59 97.76 Very High Very High Very High
INFLAMMATION 59 94.84 High High
Seronegative Spondarthritis 104 94.64 High High
Apoptosis 11 93.48 High High
Cancer 22 92.88 High High
Inflammatory Bowel Disease 22 91.80 High High
Disease 256 90.16 High High
Autoimmune Disease 19 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The IgG1 portion of alefacept can bind to Fc?
IgG1 Binding (bind) of
1) Confidence 0.01 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1208938 Disease Relevance 0.99 Pain Relevance 0.36
The capacity of IgG4 to act as RF was assessed by examining its binding capacity for human IgG1 or IgG2 or IgG3 in ELISA.
IgG1 Spec (examining) Binding (capacity) of
2) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.05 Pain Relevance 0
We first sought to confirm by ELISA that each autoimmune pancreatitis patient's serum IgG4 does act as a Novel RF, by examining its binding capacity to human IgG1 or IgG2 or IgG3.
IgG1 Spec (examining) Binding (capacity) of associated with pancreatitis
3) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.79 Pain Relevance 0.07
Adalimumab (ADA) is a subcutaneously administered, recombinant, fully human, IgG1 monoclonal antibody that binds with high affinity and specificity to human TNF-alpha, thus modulating its biologic functions and its proinflammatory effects.


IgG1 Binding (binds) of associated with adalimumab
4) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Abstract Doc Link PMC2727899 Disease Relevance 0.67 Pain Relevance 0.37
First named D2E7, ADA (Humira®; Abbott Laboratories, Abbott Park, IL, USA) is a subcutaneously administered, recombinant, fully human, IgG1 monoclonal antibody that binds with high affinity and specificity to human TNF-alpha, thus modulating its biologic functions (Plosker and Lyseng-Williamson 2007).
IgG1 Binding (binds) of associated with adalimumab
5) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727899 Disease Relevance 0.61 Pain Relevance 0.48
Finally, the genetically engineered recombinant human IgG1 monoclonal antibody adalimumab, which binds both soluble and membrane-bound TNF-?
IgG1 Binding (binds) of associated with adalimumab
6) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727880 Disease Relevance 0.88 Pain Relevance 0.71
Second, antibody-dependent cell-mediated toxicity, which is associated specifically with the IgG1 isotype, contributes to the anticancer activity.
IgG1 Binding (associated) of associated with toxicity
7) Confidence 0.00 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2868849 Disease Relevance 0.72 Pain Relevance 0

General Comments

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